The general objectives of the program in Biomedical Research to enhance offerings to, and experiences gained by the students and faculty in those areas related directly and indirectly to the health fields. The program will enable these accomplishments by: 1) providing better opportunities for initiating or expanding research activities of key faculty members who are responsible for training students in the life sciences and psychology; 2) enriching the experiences and technical know how of students in the health related areas; 3) increasing the interest of students in the health sciences as a career option, thus increasing the pool of eligible minority students for involvement in a Biomedical, Medical, or Allied Health Profession; 4) by specific training of undergraduate and graduate students in biomedical methodology and instrumentation usage in selected biomedical research problems; and 5) to culminate in publication and/or presentation of research findings. Specifically, the aims of the program will be pursued through biomedical projects conducted by participating faculty and students. Projects include developmental toxicology, aquatic mariculture, biofeedback, neurobiology, physical chemistry, enzymology and enzymatic regulation, and parasitology. The problems to be studied involve a) descriptive toxicology of PCP's in selected invertebrates, b) biofeedback control of autonomic reflexes, c) mechanistic toxicology of drugs that complex with DNA, d) neurotransmitter studies in the horseshoe crab, e) immunohistochemical studies, f) electron micrographic studies of the horseshoe crab's nervous system and the cell wall of Acanthamoeba, g) computer modeling and mental health considerations of the AIDS infection, trypanosomiasis and the molecular biology of this parasite, j) the effect of pharmacological agents on neuropeptides and other neurotransmitters, and k) biomedical ethics.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008092-19
Application #
3513268
Study Section
General Research Support Review Committee (GRS)
Project Start
1979-03-01
Project End
1994-02-28
Budget Start
1992-03-01
Budget End
1994-02-28
Support Year
19
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Tennessee State University
Department
Type
Schools of Arts and Sciences
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37209
Rana, Krupa; Whalen, Margaret (2015) Activation of protein kinase C and protein kinase D in human natural killer cells: effects of tributyltin, dibutyltin, and tetrabromobisphenol A. Toxicol Mech Methods 25:680-8
Hurd-Brown, Tasia; Udoji, Felicia; Martin, Tamara et al. (2013) Effects of DDT and triclosan on tumor-cell binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 33:495-502
Sharow, Kyle A; Temkin, Boris; Asson-Batres, Mary Ann (2012) Retinoic acid stability in stem cell cultures. Int J Dev Biol 56:273-8
Hurd, Tasia; Walker, Jasmine; Whalen, Margaret M (2012) Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 32:627-34
Taylor, Thyneice R; Whalen, Margaret M (2011) Ziram activates mitogen-activated protein kinases and decreases cytolytic protein levels in human natural killer cells. Toxicol Mech Methods 21:577-84
Buchanan, FaMitah Q; Rochette-Egly, Cecile; Asson-Batres, Mary Ann (2011) Detection of variable levels of RAR? and RAR? proteins in pluripotent and differentiating mouse embryonal carcinoma and mouse embryonic stem cells. Cell Tissue Res 346:43-51
Hurd, Tasia; Whalen, Margaret M (2011) Tetrabromobisphenol A decreases cell-surface proteins involved in human natural killer (NK) cell-dependent target cell lysis. J Immunotoxicol 8:219-27
Udoji, Felicia; Martin, Tamara; Etherton, Rachel et al. (2010) Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro. J Immunotoxicol 7:205-12
Abraha, Abraham B; Rana, Krupa; Whalen, Margaret M (2010) Role of protein kinase C in TBT-induced inhibition of lytic function and MAPK activation in human natural killer cells. Arch Environ Contam Toxicol 59:661-9
Hinkson, Natasha C; Whalen, Margaret M (2010) Hexabromocyclododecane decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 30:302-9

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