Abstract

The objectives of this program are to: 1. Promote and encourage biomedical research in the departments of Biological Sciences and Chemistry; a. Strengthen neuroscience research focus areas in biology. Dr. Asson- Batres (differentiation of olfactory tissue) will join four other faculty members (Drs. A. Blackshear, M. Ivy, R Newkirk, and B. Washington) who have ongoing research in neuroscience. This group (sixth person to be added in 1998) will have great impact on cutting edge biomedical research in the Department of Biological Sciences; b. Establish a second research focus area in microbial biology. The subprojects of Drs. Ganter and Ejiofor/johnson will form the core of this focus area. Over the next four years, departmental efforts will be to make this group comparable in size to the neuroscience group; c. Establish a biomedical research focus area in Chemistry (Drs. Chen, Karim, and Lee; and d. Strengthen the academic and research capabilities in biology and chemistry in anticipation of a Ph.D. degree program in biology. 2. Support research that addresses two major concerns among minority populations--AIDS and health problems of the elderly. 3. Promote biomedical research as a viable career option for students and provide meaningful research experience for them.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
3S06GM008092-25S1
Application #
6294426
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Eckstrand, Irene A
Project Start
1979-03-01
Project End
2002-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
25
Fiscal Year
2000
Total Cost
$222,917
Indirect Cost

  Institution

Name
Tennessee State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37209

  Publications

Rana, Krupa; Whalen, Margaret (2015) Activation of protein kinase C and protein kinase D in human natural killer cells: effects of tributyltin, dibutyltin, and tetrabromobisphenol A. Toxicol Mech Methods 25:680-8
Hurd-Brown, Tasia; Udoji, Felicia; Martin, Tamara et al. (2013) Effects of DDT and triclosan on tumor-cell binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 33:495-502
Sharow, Kyle A; Temkin, Boris; Asson-Batres, Mary Ann (2012) Retinoic acid stability in stem cell cultures. Int J Dev Biol 56:273-8
Hurd, Tasia; Walker, Jasmine; Whalen, Margaret M (2012) Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 32:627-34
Taylor, Thyneice R; Whalen, Margaret M (2011) Ziram activates mitogen-activated protein kinases and decreases cytolytic protein levels in human natural killer cells. Toxicol Mech Methods 21:577-84
Buchanan, FaMitah Q; Rochette-Egly, Cecile; Asson-Batres, Mary Ann (2011) Detection of variable levels of RAR? and RAR? proteins in pluripotent and differentiating mouse embryonal carcinoma and mouse embryonic stem cells. Cell Tissue Res 346:43-51
Hurd, Tasia; Whalen, Margaret M (2011) Tetrabromobisphenol A decreases cell-surface proteins involved in human natural killer (NK) cell-dependent target cell lysis. J Immunotoxicol 8:219-27
Udoji, Felicia; Martin, Tamara; Etherton, Rachel et al. (2010) Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro. J Immunotoxicol 7:205-12
Abraha, Abraham B; Rana, Krupa; Whalen, Margaret M (2010) Role of protein kinase C in TBT-induced inhibition of lytic function and MAPK activation in human natural killer cells. Arch Environ Contam Toxicol 59:661-9
Hinkson, Natasha C; Whalen, Margaret M (2010) Hexabromocyclododecane decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 30:302-9

Showing the most recent 10 out of 60 publications