The goals and objectives of the MBRS/SCORE Program are to enhance and assist Tennessee State University in strengthening its research and research training capacity through the following overall objectives: 1) To expand and enhance biomedical research of faculty in the Department of Biological Sciences and the Department of Chemistry at Tennessee State University. a) To establish a biomedical research focus in neuroscience and molecular biology; b) To initiate a focus in medicinal chemistry and anti-cancer / anti-AIDS agents research; c) To support research which supports the training of students in the PhD program in the Department of Biological Sciences. 2) To support community-based research that addresses two major health concerns among minorities--AIDS and better health care for the elderly; 3) Promote biomedical research collaboration within the Nashville community by: a) Participating in research collaborations at Meharry Medical College and Vanderbilt University; b) Encouraging interdepartmental research collaborations (Biological Sciences, Chemistry, Allied Health, etc.); 4) Enhance research infrastructure that will support and undergird the biomedical research activities of faculty; 5) To promote biomedical research as a viable career option for students and provide meaningful research experiences for them.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008092-30
Application #
6848331
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Zlotnik, Hinda
Project Start
1979-03-01
Project End
2006-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
30
Fiscal Year
2005
Total Cost
$310,130
Indirect Cost
Name
Tennessee State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
108814179
City
Nashville
State
TN
Country
United States
Zip Code
37209
Rana, Krupa; Whalen, Margaret (2015) Activation of protein kinase C and protein kinase D in human natural killer cells: effects of tributyltin, dibutyltin, and tetrabromobisphenol A. Toxicol Mech Methods 25:680-8
Hurd-Brown, Tasia; Udoji, Felicia; Martin, Tamara et al. (2013) Effects of DDT and triclosan on tumor-cell binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 33:495-502
Sharow, Kyle A; Temkin, Boris; Asson-Batres, Mary Ann (2012) Retinoic acid stability in stem cell cultures. Int J Dev Biol 56:273-8
Hurd, Tasia; Walker, Jasmine; Whalen, Margaret M (2012) Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 32:627-34
Taylor, Thyneice R; Whalen, Margaret M (2011) Ziram activates mitogen-activated protein kinases and decreases cytolytic protein levels in human natural killer cells. Toxicol Mech Methods 21:577-84
Buchanan, FaMitah Q; Rochette-Egly, Cecile; Asson-Batres, Mary Ann (2011) Detection of variable levels of RAR? and RAR? proteins in pluripotent and differentiating mouse embryonal carcinoma and mouse embryonic stem cells. Cell Tissue Res 346:43-51
Hurd, Tasia; Whalen, Margaret M (2011) Tetrabromobisphenol A decreases cell-surface proteins involved in human natural killer (NK) cell-dependent target cell lysis. J Immunotoxicol 8:219-27
Abraha, Abraham B; Rana, Krupa; Whalen, Margaret M (2010) Role of protein kinase C in TBT-induced inhibition of lytic function and MAPK activation in human natural killer cells. Arch Environ Contam Toxicol 59:661-9
Hinkson, Natasha C; Whalen, Margaret M (2010) Hexabromocyclododecane decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 30:302-9
Odman-Ghazi, Sabah O; Abraha, Abraham; Isom, Erica Taylor et al. (2010) Dibutyltin activates MAP kinases in human natural killer cells, in vitro. Cell Biol Toxicol 26:469-79

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