Biologically active derivatives of small cage boron hydride moieties, to be used in chemotherapy, will be synthesized. The emphasis will be on the synthesis of polyboranes containing a nitrogen attachment similar to those that have already shown confirmed activity against the leukemia P-388 test system. Functionalities will be introduced onto promising molecules in attempts to change the lipid solubilities of these systems. Structural relationships of boron compounds will be correlated to anticancer activity and other medicinal applications. Both of the two undergraduates and the graduate student, as well as the principal investigator, will carry out laboratory research projects to accomplish these goals.

Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
1990
Total Cost
Indirect Cost
Name
California State University Los Angeles
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90032
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