Abstract

The development of synthetic strategies for the formation of hemicarcerand capsules and the study of their conformational and binding properties is the focus of this work. Hemicarcerand capsules are container molecules that are proposed to undergo major temperature dependent conformational changes. Guest delivery to the bulk medium is expected during the conformational switch between fully unclosed capsule and fully opened molecule. The effects of solvents or templates as guests during the cavity-forming steps will be explored in the development of procedures to synthesize these hemicarcerand capsules in high yield. Evidence for control of the conformational switch temperatures of hemicarcerand capsules due to structural features will be sought through dynamic NMR studies. The kinetics of guest delivery and exchange in hemicarcerand capsules will be investigated with guest competition experiments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008101-30
Application #
6481214
Study Section
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
Budget End
Support Year
30
Fiscal Year
2001
Total Cost
$73,250
Indirect Cost

  Institution

Name
California State University Los Angeles
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90032

  Publications

Durvasula, Ramani S (2017) Personality Disorders and Health: Lessons Learned and Future Directions. Behav Med 43:227-232
Crespo, Noe C; Yoo, Eun Jung; Hawkins, Steven A (2011) Anthropometric and lifestyle associations of bone mass in healthy pre-menopausal Mexican and Asian American women. J Immigr Minor Health 13:74-80
Kumar, Satish; Velasco, Kriya; McCurdy, Alison (2010) X-ray, kinetics and DFT studies of photochromic substituted benzothiazolinic spiropyrans. J Mol Struct 968:13-18
Jiang, Dianlu; Li, Xiangjun; Williams, Renee et al. (2009) Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease. Biochemistry 48:7939-47
Pech, Herbe; Henry, Amanda; Khachikian, Crist S et al. (2009) Detection of geothermal phosphite using high-performance liquid chromatography. Environ Sci Technol 43:7671-5
Jiang, Dianlu; Dinh, Kim Lien; Ruthenburg, Travis C et al. (2009) A kinetic model for beta-amyloid adsorption at the air/solution interface and its implication to the beta-amyloid aggregation process. J Phys Chem B 113:3160-8
Hong, Hyun-Seok; Rana, Sandeep; Barrigan, Lydia et al. (2009) Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo. J Neurochem 108:1097-1108
Kumar, Satish; Chau, Cindy; Chau, Gordan et al. (2008) Synthesis and metal complexation properties of bisbenzospiropyran chelators in water. Tetrahedron 64:7097-7105
Kumar, Satish; Hernandez, David; Hoa, Brenda et al. (2008) Synthesis, photochromic properties, and light-controlled metal complexation of a naphthopyran derivative. Org Lett 10:3761-4
Valentine, Sonya C; Contreras, Deisy; Tan, Stephanie et al. (2008) Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California. J Clin Microbiol 46:2499-507

Showing the most recent 10 out of 42 publications