Abstract

Flavonoids are a class of nutrients found in a large number of foods, particularly fruits and vegetables. There is a large number of flavonoid subclasses, most of which have been associated with antioxidant properties important in preventing chronic diseases. Epidemiological studies have demonstrated a protective effect of flavonoids in preventing cardiovascular disease in some populations. However, there is conflicting evidence as to their efficacy in preventing cancer. The long term goal of this research is to study the bioavailability and metabolism of specific subclasses of flavonoids so that future cohort and case controlled studies can be designed to produce more definitive results regarding the link between tea consumption and improve health through prevention of chronic disease. The objective of this proposal is to study the absorptive, metabolic, and excretory processes in humans associated with the intake of gallic acid (GA) and theaflavins (TF) found in regular black tea. The results of this study will help researchers to more fully understand the metabolism of one subclass of flavonoids which is highly consumed by humans.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008205-17
Application #
6579930
Study Section
Minority Programs Review Committee (MPRC)
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
17
Fiscal Year
2002
Total Cost
$73,807
Indirect Cost

  Institution

Name
Florida International University
Department
Type
DUNS #
071298814
City
Miami
State
FL
Country
United States
Zip Code
33199

  Publications

Youngblut, JoAnne M; Brooten, Dorothy (2018) Comparison of mothers and grandmothers physical and mental health and functioning within 6 months after child NICU/PICU death. Ital J Pediatr 44:89
Hu, Ligang; Cai, Yong; Jiang, Guibin (2016) Occurrence and speciation of polymeric chromium(III), monomeric chromium(III) and chromium(VI) in environmental samples. Chemosphere 156:14-20
Youngblut, JoAnne M; Brooten, Dorothy; Blais, Kathleen et al. (2015) Health and Functioning in Grandparents After a Young Grandchild's Death. J Community Health 40:956-66
Jones, Sande Gracia; Fenkl, Eric A; Patsdaughter, Carol A et al. (2015) The Perceived Effects of Condoms on Sexual Experience: A Comparison of Older Hispanic and Non-Hispanic Men. Hisp Health Care Int 13:61-9
Menzel, L P; Tondo, C; Stein, B et al. (2015) Histology and ultrastructure of the coenenchyme of the octocoral Swiftia exserta, a model organism for innate immunity/graft rejection. Zoology (Jena) 118:115-24
Balasubramanian, Deepak; Kumari, Hansi; Jaric, Melita et al. (2014) Deep sequencing analyses expands the Pseudomonas aeruginosa AmpR regulon to include small RNA-mediated regulation of iron acquisition, heat shock and oxidative stress response. Nucleic Acids Res 42:979-98
Brown, Ellen L; Friedemann, Marie-Luise; Mauro, Ana C (2014) Use of adult day care service centers in an ethnically diverse sample of older adults. J Appl Gerontol 33:189-206
Kumari, Hansi; Murugapiran, Senthil K; Balasubramanian, Deepak et al. (2014) LTQ-XL mass spectrometry proteome analysis expands the Pseudomonas aeruginosa AmpR regulon to include cyclic di-GMP phosphodiesterases and phosphoproteins, and identifies novel open reading frames. J Proteomics 96:328-342
Friedemann, Marie-Luise; Buckwalter, Kathleen C (2014) Family Caregiver Role and Burden Related to Gender and Family Relationships. J Fam Nurs 20:313-336
Somarelli, Jason A; Mesa, Annia; Rodriguez, Carol E et al. (2014) U1 small nuclear RNA variants differentially form ribonucleoprotein particles in vitro. Gene 540:11-15

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