The overall objective of this application is to continue to develop and enhance biomedical research at the University of Arkansas at Pine Bluff. Efforts for the most part are expansions and extensions of those being conducted in Grant Application Number S06 GM08211. Specifically, faculty will engage in cutting edge biomedical research, students will participate in relevant biomedical research, students will be exposed to appropriate role models who are actively involved in biomedical research and both students and faculty will present and publish their findings in scientific journals. To accomplish these objectives, four subprojects are involved: (1) Superficial Fluid Extraction and Electrochemical Characterization of Mycotoxins, (2) Alterations in Anticancer Drug Activity by Anguidine, (3) Evaluation of Stereoisomeric Oxazolidines Derived from the Ephedrine as Prodrugs, and (4) Antineoplastic and Radioprotectant Cu(II), Mn(II), Zn(II) and Fe(III) Salicylates. This represents a reduction of two projects from the present MBRS grant. The two Principal Investigators resigned from the University. The decision is made not to request additional subprojects at this time. Also, a reduction in the number of students in two of the subprojects has been made. These are attempts to more adequately address the primary objective of MBRS - to develop more minority faculty biomedical researchers.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008211-13
Application #
2167562
Study Section
Minority Programs Review Committee (MPRC)
Project Start
1983-09-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
13
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Arkansas at Pine Bluff
Department
Type
Schools of Arts and Sciences
DUNS #
City
Pine Bluff
State
AR
Country
United States
Zip Code
71601
Bakhtiar, R; Walker, R B; Dholakia, V N (1998) The effect of hydroxypropyl-beta-cyclodextrin on the kinetics of hydrolysis of an oxazolidine prodrug. Rapid Commun Mass Spectrom 12:1417-8
Walker, R B; Dholakia, V N; Brasfield, K L et al. (1998) Effect of hydroxypropyl-beta-cyclodextrin on the central stimulant activity of (-)-ephedrine and an oxazolidine prodrug in rats. Gen Pharmacol 30:725-31
Bakhtiar, R; Hop, C E; Walker, R B (1997) Effect of cyclodextrins on the hydrolysis of an oxazolidine prodrug of (1R,2S)-(-)-ephedrine-cis-2-(4-methoxyphenyl)-3, 4-dimethyl-5-phenyloxazolidine. Rapid Commun Mass Spectrom 11:598-602
Walker, R B; Fitz, L D; Williams, L M et al. (1996) The effect on ephedrine prodrugs on locomotor activity in rats. Gen Pharmacol 27:109-11
Walker, R B; Wood, D M; Akmal, M M et al. (1992) Effects of oxazolidines derived from (-) ephedrine in the rat. Gen Pharmacol 23:729-32
Walker, R B; Wood, D M; Akmal, M M (1990) Hyperthermic and anorectic effects of oxazolidines derived from L-ephedrine in rats. Life Sci 47:595-600