The overall objective of this application is to increase the number of faculty members at the University of Arkansas at Pine Bluff engaging in competitive biomedical and behavioral research. To accomplish this objective, four subprojects are included. Two of these are regular research proposals and the other three are pilot studies. The project titles are 1) """"""""Oxazolidines as Potential Pro-drugs: Stability and Pharmacological Studies"""""""", ) """"""""Gastrin Gene Regulation""""""""; 3) """"""""Social Conflict and Group Processes in Social Dilemmas""""""""; 4) """"""""Synthesis and Anti-convulsant Activity of 2-Carbethoxymethyl Anilines"""""""".
Specific aims are five publications in refereed journals, five presentations at professional meetings, and five additional funded research proposals all by the end of the project period. Competitive research will held provide a solid foundation for students to pursue graduate studies in biomedical and behavioral studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008211-16
Application #
6018273
Study Section
Minority Programs Review Committee (MPRC)
Project Start
1983-09-01
Project End
2002-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Arkansas at Pine Bluff
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
City
Pine Bluff
State
AR
Country
United States
Zip Code
71601
Bakhtiar, R; Walker, R B; Dholakia, V N (1998) The effect of hydroxypropyl-beta-cyclodextrin on the kinetics of hydrolysis of an oxazolidine prodrug. Rapid Commun Mass Spectrom 12:1417-8
Walker, R B; Dholakia, V N; Brasfield, K L et al. (1998) Effect of hydroxypropyl-beta-cyclodextrin on the central stimulant activity of (-)-ephedrine and an oxazolidine prodrug in rats. Gen Pharmacol 30:725-31
Bakhtiar, R; Hop, C E; Walker, R B (1997) Effect of cyclodextrins on the hydrolysis of an oxazolidine prodrug of (1R,2S)-(-)-ephedrine-cis-2-(4-methoxyphenyl)-3, 4-dimethyl-5-phenyloxazolidine. Rapid Commun Mass Spectrom 11:598-602
Walker, R B; Fitz, L D; Williams, L M et al. (1996) The effect on ephedrine prodrugs on locomotor activity in rats. Gen Pharmacol 27:109-11
Walker, R B; Wood, D M; Akmal, M M et al. (1992) Effects of oxazolidines derived from (-) ephedrine in the rat. Gen Pharmacol 23:729-32
Walker, R B; Wood, D M; Akmal, M M (1990) Hyperthermic and anorectic effects of oxazolidines derived from L-ephedrine in rats. Life Sci 47:595-600