Semiquinones are important intermediates postulated to be involved in the cytotoxic activities of quinone-containing drugs. The efficacy of these activities should depend on the thermodynamic stability of the semiquinones. This stability depends on the internal structure of the semiquinones and on the semiquinone-environment infractions. It is the purpose of this subproject to determine the thermodynamic parameters controlling the internal stability of semiquinones as well as semiquinone-environment interactions. Once these thermodynamic parameters are known, their effect on semiquinone redox reactions with oxygen, including lipid peroxidation, will be determined. Students will be trained in this subproject in all the aspects of the biomedical research process with the purpose of promoting them to biomedical research careers.

Project Start
1997-03-01
Project End
1998-02-28
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
14
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Puerto Rico at Humacao
Department
Type
DUNS #
City
Humacao
State
PR
Country
United States
Zip Code
00791
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