The objective of this proposal is to establish a bioassay for high throughput screening of plant extracts and compounds against tuberculosis. The assay will be used for screening the flora of Puerto Rico for potential bioactives against these mycobacteria. Endemic and rare plant species as well as plants belonging to genera reported to have anti-tuberculosis activity will be assigned highest priority. In addition, detailed fractionation of the most active six plants found so far (against tuberculosis) will be carried out, and the active will be identified and characterized. The research will be carried out by the P.I., a research associate and a medical technologist. The assay will complement an ongoing anti-HIV/cytotoxic screen, thus increasing the likelihood of discovering potential leads against three important diseases. Graduate and undergraduate students will be involved in the research program under the supervision of the P.I. .
| Rijpma, Sanna R; van der Velden, Maarten; González-Pons, Maria et al. (2016) Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites. Cell Microbiol 18:369-83 |
| Padín-Irizarry, Vivian; Colón-Lorenzo, Emilee E; Vega-Rodríguez, Joel et al. (2016) Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage. Free Radic Biol Med 95:43-54 |
| Jardón, Javier; Izquierdo, Natalio J; Renta, Jessica Y et al. (2016) Ocular Findings in Patients with the Hermansky-Pudlak Syndrome (Types 1 and 3). Ophthalmic Genet 37:89-94 |
| Rivera-Peña, Bianca; Ruíz-Fullana, Francisco J; Vélez-Reyes, Germán L et al. (2016) HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients. Infect Agent Cancer 11:47 |
| Velásquez-Martínez, Maria C; Vázquez-Torres, Rafael; Rojas, Legier V et al. (2015) Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons. Neuropharmacology 88:110-21 |
| Vega-Rodríguez, Joel; Pastrana-Mena, Rebecca; Crespo-Lladó, Keila N et al. (2015) Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin. PLoS One 10:e0128212 |
| Zenón, Frances; Cantres-Rosario, Yisel; Adiga, Radhika et al. (2015) HIV-infected microglia mediate cathepsin B-induced neurotoxicity. J Neurovirol 21:544-58 |
| Segarra, Annabell C; Torres-Díaz, Yvonne M; Silva, Richard D et al. (2014) Estrogen receptors mediate estradiol's effect on sensitization and CPP to cocaine in female rats: role of contextual cues. Horm Behav 65:77-87 |
| Ortiz, A P; Unger, E R; Muñoz, C et al. (2014) Cross-sectional study of HPV-16 infection in a population-based subsample of Hispanic adults. BMJ Open 4:e004203 |
| Rosas, Odrick R; Torrado, Aranza I; Santiago, Jose M et al. (2014) Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Neural Regen Res 9:2164-73 |
Showing the most recent 10 out of 174 publications
