Abstract

A cross-sectional study is proposed to study age related variation in closure of the sacral spines to properly interpret sacral anomalies of closure being studied in other contexts. We propose to test the hypothesis that age of closure is later, and shows greater variation by race and sex, than is generally reported in the literature. We further hypothesize that racial and sexual patterns of closure are governed by differences in the average rate of skeletal maturation in these categories, but that superimposed on this pattern of normal variation are genetic and environmental predispositions to spina bifida in its various manifestations. Our research protocol is designed to test these assumptions as well.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008225-06
Application #
3877682
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Herbert H. Lehman College
Department
Type
DUNS #
620128301
City
New York
State
NY
Country
United States
Zip Code
10468

  Publications

Zheng, Zhi-Liang (2017) Ras and Rho GTPase regulation of Pol II transcription: A shortcut model revisited. Transcription 8:268-274
Zhang, Bo; Yang, Guohua; Chen, Yu et al. (2016) C-terminal domain (CTD) phosphatase links Rho GTPase signaling to Pol II CTD phosphorylation in Arabidopsis and yeast. Proc Natl Acad Sci U S A 113:E8197-E8206
Guerrero-Berroa, Elizabeth; Kluger, Alan; Schmeidler, James et al. (2014) Neuropsychological and neuropsychiatric prediction of global cognitive status among older Spanish-speaking Hispanics and English-speaking whites. J Geriatr Psychiatry Neurol 27:266-75
Zhang, Bo; Pasini, Rita; Dan, Hanbin et al. (2014) Aberrant gene expression in the Arabidopsis SULTR1;2 mutants suggests a possible regulatory role for this sulfate transporter in response to sulfur nutrient status. Plant J 77:185-97
Sailor, Kevin; Brooks, Patricia J (2014) Do part-whole relations produce facilitation in the picture-word interference task? Q J Exp Psychol (Hove) 67:1768-85
Gharbaran, Rajendra; Alvarado, Susana; Aisemberg, Gabriel O (2014) Regional and segmental differences in the embryonic expression of a putative leech Hox gene, Lox2, by central neurons immunoreactive to FMRFamide-like neuropeptides. Invert Neurosci 14:51-8
Gharbaran, Rajendra; Aisemberg, Gabriel O (2013) Identification of leech embryonic neurons that express a Hox gene required for the differentiation of a paired, segment-specific motor neuron. Int J Dev Neurosci 31:105-15
Gharbaran, Rajendra; Aisemberg, Gabriel O; Alvarado, Susana (2012) Segmental and regional differences in neuronal expression of the leech Hox genes Lox1 and Lox2 during embryogenesis. Cell Mol Neurobiol 32:1243-53
Vallabhaneni, Ratnakar; Bradbury, Louis M T; Wurtzel, Eleanore T (2010) The carotenoid dioxygenase gene family in maize, sorghum, and rice. Arch Biochem Biophys 504:104-11
Acuna, Ulyana Munoz; Figueroa, Mario; Kavalier, Adam et al. (2010) Benzophenones and biflavonoids from Rheedia edulis. J Nat Prod 73:1775-9

Showing the most recent 10 out of 67 publications