Investigators have attributed racial differences in disease occurrences in mortality to socioeconomic status. TO verify this hypothesis, we have integrated analysis of data from Georgia Medicaid claim files from 1988 to 1992. Counts, rates and racial differences of newly and previously diagnosed cases of hypertension and cervices cancer in the year 1992 were calculated. The racial disparity in cervical cancer rates was diminished in the rural areas, but not in the urban areas. Approximately one million people in Georgia receive Medicaid assistance. Health issues among them are important, but the Medicaid data has rarely been used. We propose to conduct similar to those previously conduct for hypertension and cervical cancer. We will attempt to complete studies on breast, prostate, colorectal and lung cancers, and hypertension treatment effectiveness. We will study breast cancer in year one, prostate cancer in year two, colorectal cancer in year three, and lung cancer in year four. During this 4-year period, we will study the treatment effectiveness of hypertension as well. Observations on prevalence and new claim rates of these disease will emphasize differences by gender,r ace, age and geographic factors. We would like to develop at least one abstract and one manuscript annually. This project will also provide students with the hands-on opportunity to become capable in the use of Medicaid data to study health issues among disadvantaged populations.

Project Start
1998-08-01
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Morehouse School of Medicine
Department
Type
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30310
Wilson, Nana O; Solomon, Wesley; Anderson, Leonard et al. (2013) Pharmacologic inhibition of CXCL10 in combination with anti-malarial therapy eliminates mortality associated with murine model of cerebral malaria. PLoS One 8:e60898
Igietseme, Joseph U; Omosun, Yusuf; Partin, James et al. (2013) Prevention of Chlamydia-induced infertility by inhibition of local caspase activity. J Infect Dis 207:1095-104
Wilson, Nana; Driss, Adel; Solomon, Wesley et al. (2013) CXCL10 gene promoter polymorphism -1447A>G correlates with plasma CXCL10 levels and is associated with male susceptibility to cerebral malaria. PLoS One 8:e81329
Kim, Teayoun; Zhelyabovska, Olga; Liu, Jian et al. (2013) Generation of an inducible, cardiomyocyte-specific transgenic mouse model with PPAR ?/? overexpression. Methods Mol Biol 952:57-65
Shelton, Martin N; Huang, Ming-Bo; Ali, Syed A et al. (2012) Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release. J Virol 86:406-19
Campbell, Patrick E; Isayev, Olexandr; Ali, Syed A et al. (2012) Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling. J Mol Model 18:4603-13
Liu, Mingli; Amodu, Audu S; Pitts, Sidney et al. (2012) Heme mediated STAT3 activation in severe malaria. PLoS One 7:e34280
Wilson, Nana O; Ceesay, Fatou K; Hibbert, Jacqueline M et al. (2012) Pregnancy outcomes among patients with sickle cell disease at Korle-Bu Teaching Hospital, Accra, Ghana: retrospective cohort study. Am J Trop Med Hyg 86:936-42
Wilson, Nana O; Jain, Vidhan; Roberts, Christina E et al. (2011) CXCL4 and CXCL10 predict risk of fatal cerebral malaria. Dis Markers 30:39-49
Sarfo, Bismark Y; Wilson, Nana O; Bond, Vincent C et al. (2011) Plasmodium berghei ANKA infection increases Foxp3, IL-10 and IL-2 in CXCL-10 deficient C57BL/6 mice. Malar J 10:69

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