This proposal requests funding for an upgrade of the current Siemens MAGNETOM Trio 3T Human MRI System in the Harvard Center for Brain Science to the new state-of-the- art Siemens MAGNETOM Prisma Fit System. This upgrade will have a significant impact on the neuroimaging research of our NIH-funded projects. The objectives of those funded projects include elucidating the relationship between brain deposits of amyloid, memory impairment, and Alzheimer's disease; studying the atrophy in the elderly of brain regions involved in social cognition, and the development and aging of cognitive control over behavior; delineating the contributions of the hippocampus to episodic simulation and constructive memory; studying the biological basis of emergent increases in daily-life anxiety, and clinical anxiety disorders, in late childhood and early adolescence; and understanding the neural mechanisms involved in object ensemble representation. The upgrade will greatly enhance image quality, reduce scan times, and enable powerful new methods such Simultaneous Multi-Slice (multiband) acquisitions.
| Ksander, John C; Paige, Laura E; Johndro, Hunter A et al. (2018) Cultural specialization of visual cortex. Soc Cogn Affect Neurosci 13:709-718 |
| Tomov, Momchil S; Dorfman, Hayley M; Gershman, Samuel J (2018) Neural Computations Underlying Causal Structure Learning. J Neurosci 38:7143-7157 |
| Blanchard, Tommy C; Gershman, Samuel J (2018) Pure correlates of exploration and exploitation in the human brain. Cogn Affect Behav Neurosci 18:117-126 |
| Paige, Laura E; Ksander, John C; Johndro, Hunter A et al. (2017) Cross-cultural differences in the neural correlates of specific and general recognition. Cortex 91:250-261 |
| Thakral, Preston P; Benoit, Roland G; Schacter, Daniel L (2017) Imagining the future: The core episodic simulation network dissociates as a function of timecourse and the amount of simulated information. Cortex 90:12-30 |
| Braga, Rodrigo M; Buckner, Randy L (2017) Parallel Interdigitated Distributed Networks within the Individual Estimated by Intrinsic Functional Connectivity. Neuron 95:457-471.e5 |
| Thakral, Preston P; Benoit, Roland G; Schacter, Daniel L (2017) Characterizing the role of the hippocampus during episodic simulation and encoding. Hippocampus 27:1275-1284 |
| Bernhard, Regan M; Chaponis, Jonathan; Siburian, Richie et al. (2016) Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment. Soc Cogn Affect Neurosci 11:1872-1881 |
