Funding is requested to obtain a Bruker Biospin TXO CryoProbe optimized for carbon-13 detection. The CryoProbe will be installed on an existing Bruker Biospin 800 MHz NMR spectrometer. The requested CryoProbe is essential to the over-riding purpose of the New York Structural Biology Center (NYSBC), a consortium of nine research institutions in New York State, to support the particular aims of the NIH-funded research of the major and minor users of the spectrometer. Research conducted on the 800 MHz instrument ranges from fundamental studies of structure/function of biomolecules, to elucidation of mechanisms of pathogenesis, to discovery of novel lead compounds to pharmaceutical applications. The requested TXO CryoProbe uniquely complements the existing TCI probes (optimized for hydrogen-1 detection) and will dramatically enhance the capacity of the 800 MHz NMR spectrometer to conduct this research.
The New York Structural Biology Center (NYSBC), a consortium of nine research institutions in New York State, houses and supports ultra-high field (>600 MHz) NMR spectrometers used by scientists at member institutions. NMR spectroscopy is a critical method used across biological research conducted at member institutions and maintaining state-of-the-art instrumentation is essential to the mission of NYSBC. The requested TXO CryoProbe optimized for direct observation of carbon-13, to be installed on an existing 800 MHz NMR spectrometer at NYSBC, provides unique capabilities and will enable research ranging from understanding fundamental biological processes in normal and pathological states to discovery of potential new drugs for treatment of cancer and other diseases.
