Abstract

This application is for partial funding for the purchase of a 50OMHz NMR spectrometer. The instrument is to be used for biomedical research, including NMR spectroscopy of solutions, cells, tissues and organs, and for NMR microscopic imaging of cells, tissues, and small organisms. Emphasis will be on spectroscopy requiring high sensitivity, such as studies of biopsy specimens and single retinae, on those requiring high spectral dispersion, and on investigations involving advanced techniques, such as multiple quantum editing, not otherwise available. The microscopic studies will focus on those applications, to cell cultures, tissues specimens and developing organisms, requiring the highest sensitivity, speed and resolution.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR006243-01
Application #
3520942
Study Section
Special Emphasis Panel (SSS (R1))
Project Start
1991-06-11
Project End
1992-06-10
Budget Start
1991-06-11
Budget End
1992-06-10
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Illinois Urbana-Champaign
Department
Type
Schools of Medicine
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820

  Publications

Wang, Steven J; Brechbiel, Martin; Wiener, Erik C (2003) Characteristics of a new MRI contrast agent prepared from polypropyleneimine dendrimers, generation 2. Invest Radiol 38:662-8
Konda, S D; Aref, M; Wang, S et al. (2001) Specific targeting of folate-dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts. MAGMA 12:104-13
Konda, S D; Aref, M; Brechbiel, M et al. (2000) Development of a tumor-targeting MR contrast agent using the high-affinity folate receptor: work in progress. Invest Radiol 35:50-7
Yang, X L; Hubbard , R B; Lee, M et al. (1999) Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs. Nucleic Acids Res 27:4183-90
Robinson, H; Gao, Y G; Bauer, C et al. (1998) 2'-Deoxyisoguanosine adopts more than one tautomer to form base pairs with thymidine observed by high-resolution crystal structure analysis. Biochemistry 37:10897-905
Subramanian, R; Lam, M M; Webb, A G (1998) RF microcoil design for practical NMR of mass-limited samples. J Magn Reson 133:227-31
Yang, Y; Xu, S; Dawson, M J et al. (1997) Diffusion measurement in phantoms and tissues using SLIM localization. J Magn Reson 129:161-4
Robinson, H; Priebe, W; Chaires, J B et al. (1997) Binding of two novel bisdaunorubicins to DNA studied by NMR spectroscopy. Biochemistry 36:8663-70
Xu, S; Yang, Y; Gregory, C D et al. (1997) Biochemical heterogeneity in hysterectomized uterus measured by 31P NMR using SLIM localization. Magn Reson Med 37:736-43
Bauer, C; Wang, A H (1997) Bridged cobalt amine complexes induce DNA conformational changes effectively. J Inorg Biochem 68:129-35

Showing the most recent 10 out of 22 publications