Abstract

This proposal requests a triple-resonance 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer, which will be located in the College of Pharmacy at the University of Arizona. Common features of the user grouip are (1) NIH supported research programs with a significant NMR component and (2) immediate need for high-field NMR instrumentation not available in the proximity of the College of Pharmacy (all users are located in the College of Pharmacy). Most major users have just relocated to the University of Arizona, and access to a high-field NMR spectrometer is critical to the maximum productivity and success of these projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR016659-01
Application #
6441144
Study Section
Special Emphasis Panel (ZRG1-PB (01))
Program Officer
Tingle, Marjorie
Project Start
2002-05-01
Project End
2003-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
1
Fiscal Year
2002
Total Cost
$393,000
Indirect Cost

  Institution

Name
University of Arizona
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Kaiser, Christine E; Gokhale, Vijay; Yang, Danzhou et al. (2013) Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay. Top Curr Chem 330:1-21
Chen, Yuwei; Yang, Danzhou (2012) Sequence, stability, and structure of G-quadruplexes and their interactions with drugs. Curr Protoc Nucleic Acid Chem Chapter 17:Unit17.5
Chen, Yuwei; Agrawal, Prashansa; Brown, Robert V et al. (2012) The major G-quadruplex formed in the human platelet-derived growth factor receptor * promoter adopts a novel broken-strand structure in K+ solution. J Am Chem Soc 134:13220-3
Mathad, Raveendra I; Hatzakis, Emmanuel; Dai, Jixun et al. (2011) c-MYC promoter G-quadruplex formed at the 5'-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability. Nucleic Acids Res 39:9023-33
Dai, Jixun; Carver, Megan; Hurley, Laurence H et al. (2011) Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design. J Am Chem Soc 133:17673-80
Mathad, Raveendra I; Yang, Danzhou (2011) G-quadruplex structures and G-quadruplex-interactive compounds. Methods Mol Biol 735:77-96
Dai, Jixun; Hatzakis, Emmanuel; Hurley, Laurence H et al. (2010) I-motif structures formed in the human c-MYC promoter are highly dynamic--insights into sequence redundancy and I-motif stability. PLoS One 5:e11647
Yang, Danzhou; Okamoto, Keika (2010) Structural insights into G-quadruplexes: towards new anticancer drugs. Future Med Chem 2:619-46
Zhang, Zhenjiang; Dai, Jixun; Veliath, Elizabeth et al. (2010) Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures. Nucleic Acids Res 38:1009-21
Hatzakis, Emmanuel; Okamoto, Keika; Yang, Danzhou (2010) Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop isomers formed in the nuclease hypersensitive element in the human c-Myc promoter: effect of loops and flanking segments on the stability of parallel-stranded intramolecul Biochemistry 49:9152-60

Showing the most recent 10 out of 27 publications