Magnetic resonance imaging (MRI) provides exquisite soft tissue contrast. Positron emission tomography provides exquisite molecular and biochemical information, but often lacks anatomic contrast. This latter fact has led to the development of combined PET-CT (computed tomography) scanners in order to use x-ray CT to provide the anatomic contrast lacking in the PET. The possibility of combining an MRI and PET scanner has been experimentally documented, however the high magnetic field creates many challenges in engineering the final instrument. This proposal seeks to obtain funding to purchase a prototype PET-MRI scanner to be built by Siemens-CPS Instrumentation. Although a first generation instrument, this instrument would allow for collection of high quality soft-tissue anatomic contrast using a 1.5T scanner while simultaneously acquiring high quality PET data with a spatial resolution on the order of 3 mm from a concentric PET detector. This proposal represents a collection of NIH-funded projects, all of which would greatly benefit from the added anatomic and metabolic information that the MRI can provide to state-of-the-art PET studies in a number of different disease processes. This scanner would afford us the opportunity of working out in detail the limitations and advantages of such a system to help tailor future generation scanners. This proposal reflects the belief of the allied investigators that the future of PET scanning may well be found in such devices, and that immediate testing, in both basic science and clinical settings, will afford us an unparalleled opportunity to improve the quantitative accuracy of PET scanning. ? ? ?
| Kang, Dong-Wha; Kim, Dongho; Chang, Li-Hung et al. (2018) Structural and Functional Connectivity Changes Beyond Visual Cortex in a Later Phase of Visual Perceptual Learning. Sci Rep 8:5186 |
| Schoenberger, Matthias; Schroeder, Frederick A; Placzek, Michael S et al. (2018) In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates. ACS Chem Neurosci 9:298-305 |
| Strebl, Martin G; Yang, Jane; Isaacs, Lyle et al. (2018) Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET. Mol Imaging 17:1536012118799838 |
| Hooker, Jacob M; Strebl, Martin G; Schroeder, Frederick A et al. (2017) Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine. Sci Rep 7:42136 |
| Wang, Changning; Schroeder, Frederick A; Hooker, Jacob M (2017) Development of New Positron Emission Tomography Radiotracer for BET Imaging. ACS Chem Neurosci 8:17-21 |
| Sander, Christin Y; Mandeville, Joseph B; Wey, Hsiao-Ying et al. (2017) Effects of flow changes on radiotracer binding: Simultaneous measurement of neuroreceptor binding and cerebral blood flow modulation. J Cereb Blood Flow Metab :271678X17725418 |
| Hansen, Hanne D; Mandeville, Joseph B; Sander, Christin Y et al. (2017) Functional Characterization of 5-HT1B Receptor Drugs in Nonhuman Primates Using Simultaneous PET-MR. J Neurosci 37:10671-10678 |
| Sander, Christin Y; Hesse, Swen (2017) News and views on in-vivo imaging of neurotransmission using PET and MRI. Q J Nucl Med Mol Imaging 61:414-428 |
| Strebl, Martin G; Campbell, Arthur J; Zhao, Wen-Ning et al. (2017) HDAC6 Brain Mapping with [18F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination. ACS Cent Sci 3:1006-1014 |
| Wey, Hsiao-Ying; Gilbert, Tonya M; Zürcher, Nicole R et al. (2016) Insights into neuroepigenetics through human histone deacetylase PET imaging. Sci Transl Med 8:351ra106 |
Showing the most recent 10 out of 44 publications
