The goal of this proposal is to acquire funds to purchase a Scanco VivaCT 75 high speed in vivo micro- computed tomography ( The requested Scanco VivaCT 75 high-speed in vivo micro-computed tomography (?CT) instrument will provide the means to generate quantitative data that is necessary for evaluating bone phenotypes, bone pathologies and novel therapeutic strategies to inhibit bone resorption and stimulate bone formation. This instrument will contribute to the treatment of skeletal disorders in a number of major areas of health concern: 1) hard-to-heal skeletal defects due to trauma, aging, metabolic diseases and tumor resection;2) the debilitating metastatic diseases of bone;and 3) bone loss in osteoarthritis and rheumatoid arthritis that affects millions of people worldwide.Public Health Relevance