Abstract

The College of Chemistry X-ray Crystallography Facility at the University of California, Berkeley is requesting a total of $500,000 in funding from the National Institutes of Health for the purchase of a new single crystal X-ray diffractometer. The facility is oversubscribed as it is and current instrumentation in the laboratory is beginning to reach the end of its useful life and will need to be replaced shortly. In addition, new advances in technology allow newer instrumentation to be much more sensitive and versatile than first generation CCD diffractometers. Considering the amount of NIH-supported structures solved in this facility (over 250 per year), a new x-ray diffractometer for the facility will instantly improve the quality and range of data we are able to collect for NIH researchers.

Public Health Relevance

The determination of the chemical and absolute structure of newly synthesized compounds is of utmost importance for potential drug targets used to treat diseases and illnesses. Single Crystal X-ray Crystallography is the one technique that can unambiguously give the chemical and absolute structure information necessary in one experiment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR027172-01
Application #
7794643
Study Section
Special Emphasis Panel (ZRG1-BCMB-D (30))
Program Officer
Levy, Abraham
Project Start
2010-07-15
Project End
2011-07-14
Budget Start
2010-07-15
Budget End
2011-07-14
Support Year
1
Fiscal Year
2010
Total Cost
$500,000
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Durr, Rebecca A; Haberer, Danny; Lee, Yea-Lee et al. (2018) Orbitally Matched Edge-Doping in Graphene Nanoribbons. J Am Chem Soc 140:807-813
Forse, Alexander C; Gonzalez, Miguel I; Siegelman, Rebecca L et al. (2018) Unexpected Diffusion Anisotropy of Carbon Dioxide in the Metal-Organic Framework Zn2(dobpdc). J Am Chem Soc 140:1663-1673
Hu, Xirui; Lim, Pharath; Fairhurst, Rick M et al. (2018) Synthesis and Study of the Antimalarial Cardamom Peroxide. Tetrahedron 74:3358-3369
Peacock, D Matthew; Jiang, Quan; Hanley, Patrick S et al. (2018) Reductive Elimination from Phosphine-Ligated Alkylpalladium(II) Amido Complexes To Form sp3 Carbon-Nitrogen Bonds. J Am Chem Soc 140:4893-4904
Kiel, Gavin R; Samkian, Adrian E; Nicolay, Amélie et al. (2018) Titanocene-Mediated Dinitrile Coupling: A Divergent Route to Nitrogen-Containing Polycyclic Aromatic Hydrocarbons. J Am Chem Soc 140:2450-2454
Mukai, Ken; de Sant'Ana, Danilo Pereira; Hirooka, Yasuo et al. (2018) Bioinspired chemical synthesis of monomeric and dimeric stephacidin A congeners. Nat Chem 10:38-44
Smith, Patrick W; Tilley, T Don (2018) Base-Free Iron Hydrosilylene Complexes via an ?-Hydride Migration that Induces Spin Pairing. J Am Chem Soc 140:3880-3883
Xu, Gong; Elkin, Masha; Tantillo, Dean J et al. (2017) Traversing Biosynthetic Carbocation Landscapes in the Total Synthesis of Andrastin and Terretonin Meroterpenes. Angew Chem Int Ed Engl 56:12498-12502
Nguyen, Andy I; Suess, Daniel L M; Darago, Lucy E et al. (2017) Manganese-Cobalt Oxido Cubanes Relevant to Manganese-Doped Water Oxidation Catalysts. J Am Chem Soc 139:5579-5587
Brown, Alexandra C; Altman, Alison B; Lohrey, Trevor D et al. (2017) Hydride oxidation from a titanium-aluminum bimetallic complex: insertion, thermal and electrochemical reactivity. Chem Sci 8:5153-5160

Showing the most recent 10 out of 97 publications