Facility Core: Inhalation Exposure Facility, UTMB. Successful completion of the proposed ARCH program is critically dependent on the exposure of both whole animal models and in vitro cell culture systems to 1,3-butadiene. UTMB has recently completed construction of state-of-the-art facility which enables tightly controlled exposures of laboratory rodents and model systems to gases and vapors. The facility contains animal exposure chambers; a CO2 incubator equipped with glass isolation chambers; air handling systems for supply air production and exhaust gas removal; equipment for pollutant generation, mixing, and delivery, gas phase analysis equipment for chamber and in vitro system monitoring; and an animal holding room containing an HEPA fiber isolation unit. The exposure system incorporates default safety measures to ensure protection of both laboratory personnel and animals. Exposure protocols must first receive approval from both the Animal Care and Use Committee and for studies proposed under all three UTMB R-01 projects and two of the initial pilot projects to be conducted by Southern University. In addition, the facility will offer a hands-on training opportunity for both faculty and students at Southern University to learn fundamental principles of inhalation toxicology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Minority Biomedical Research Support Thematic Project Grants (S11)
Project #
1S11ES010018-01
Application #
6261039
Study Section
Special Emphasis Panel (ZES1-DPB-A (S1))
Project Start
1999-08-15
Project End
2004-07-31
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Southern University A&M Col Baton Rouge
Department
Type
DUNS #
City
Baton Rouge
State
LA
Country
United States
Zip Code
70813
Yadavilli, Sridevi; Martinez-Ceballos, Eduardo; Snowden-Aikens, Janana et al. (2007) Diepoxybutane activates the mitochondrial apoptotic pathway and mediates apoptosis in human lymphoblasts through oxidative stress. Toxicol In Vitro 21:1429-41
Dupard-Julien, Catrina L; Kandlakunta, Bhaskarachary; Uppu, Rao M (2007) Determination of epoxides by high-performance liquid chromatography following derivatization with N,N-diethyldithiocarbamate. Anal Bioanal Chem 387:1027-32
Sathishkumar, K; Xi, Xiaochun; Martin, Roy et al. (2007) Cholesterol secoaldehyde, an ozonation product of cholesterol, induces amyloid aggregation and apoptosis in murine GT1-7 hypothalamic neurons. J Alzheimers Dis 11:261-74
Nossaman, Bobby D; Bivalacqua, Trinity J; Champion, Hunter C et al. (2007) Analysis of vasodilator responses to peroxynitrite in the hindlimb vascular bed of the cat. J Cardiovasc Pharmacol 50:358-66
Chen, Zhenping; Knutson, Eugene; Wang, Shuo et al. (2007) Stabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination. J Biol Chem 282:29284-95
Wu, Tzu G; Rose 2nd, William A; Albrecht, Thomas B et al. (2007) IFN-alpha-induced murine B16 melanoma cancer vaccine cells: induction and accumulation of cell-associated IL-15. J Interferon Cytokine Res 27:13-22
Wickliffe, Jeffrey K; Herring, Stacy M; Hallberg, Lance M et al. (2007) Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene. Chem Biol Interact 166:226-31
Nossaman, Bobby D; Baber, Syed R; Nazim, Mohammed M et al. (2007) Acetaminophen, phenacetin and dipyrone do not modulate pressor responses to arachidonic Acid or to pressor agents. Pharmacology 80:249-60
Sathishkumar, K; Rangan, Viswanathan; Gao, Xueli et al. (2007) Methyl vinyl ketone induces apoptosis in murine GT1-7 hypothalamic neurons through glutathione depletion and the generation of reactive oxygen species. Free Radic Res 41:469-77
Nossaman, Bobby D; Baber, Syed R; Nazim, Mohammed M et al. (2007) Differential effects of losartan and candesartan on vasoconstrictor responses in the rat. Can J Physiol Pharmacol 85:360-71

Showing the most recent 10 out of 26 publications