The explosive increase in our understanding of the molecular and cellular basis of disease processes is generating exciting opportunities for well-trained scientists to explore new approaches to treatment of complex diseases, such as those related to alcohol abuse and alcoholism. The purpose of the Research Training Program """"""""Alcoholic Tissue Injury"""""""" is to train qualified predoctoral and postdoctoral fellows in the pathobiology of experimental alcoholic injury to develop the requisite skills to explore these new directions. The program consists of a predoctoral program that will support 7 candidates who are preparing for a Ph.D. in Molecular Cell Biology or a combined M.D. /Ph.D. degree, with a specialization in Alcohol Research. The postdoctoral program provides specialized research training in topics relevant for alcohol research for 5 candidates holding a Ph.D. or M.D. degree. Candidates are recruited from a national pool of highly qualified applicants and special emphasis is placed on the recruitment of qualified minority candidates for both training programs. Predoctoral students who are committed to alcohol-related research will normally be supported through most of their training period. The postdoctoral training period will normally be for two or three years. The candidates will receive their training in the department of Pathology, Anatomy and Cell Biology, which occupies 25,000 sq. ft. of research space in Thomas Jefferson University in Philadelphia. Twenty-four faculty members, who have or are applying for USPHS-supported research projects related to alcoholism, are involved in the training effort, In addition, another 19 faculty with relevant research and interest are available to provide additional training resources. A multidisciplinary approach will emphasize concepts and research techniques of cellular and molecular biology, biophysics, biochemistry, developmental biology, neurobiology, molecular virology and systems biology. Trainees will develop insight into normal and pathologic processes that are influenced or altered by the presence of ethanol or by chronic alcohol intake. The research projects are associated with the Thomas Jefferson University Alcohol Research Center and focus on the effects of ethanol at the cellular and molecular level. In addition to research training in the laboratory, the training will include a wide range of courses, workshops, journal club sessions and research seminars. The program has a strong record of successful trainee achievements. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007463-21
Application #
7083583
Study Section
Special Emphasis Panel (ZAA1-HH (01))
Program Officer
Gentry, Thomas
Project Start
1986-07-01
Project End
2010-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
21
Fiscal Year
2006
Total Cost
$444,932
Indirect Cost
Name
Thomas Jefferson University
Department
Pathology
Type
Schools of Medicine
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Gubbiotti, Maria A; Seifert, Erin; Rodeck, Ulrich et al. (2018) Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin. J Biol Chem 293:16940-16950
Cook, Daniel; Achanta, Sirisha; Hoek, Jan B et al. (2018) Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics. BMC Syst Biol 12:86
Hurst, Stephen; Hoek, Jan; Sheu, Shey-Shing (2017) Mitochondrial Ca2+ and regulation of the permeability transition pore. J Bioenerg Biomembr 49:27-47
Schaefer, Liliana; Tredup, Claudia; Gubbiotti, Maria A et al. (2017) Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. FEBS J 284:10-26
Kuttippurathu, Lakshmi; Patra, Biswanath; Cook, Daniel et al. (2017) Pattern analysis uncovers a chronic ethanol-induced disruption of the switch-like dynamics of C/EBP-? and C/EBP-? genome-wide binding during liver regeneration. Physiol Genomics 49:11-26
Torres, Annabel; Gubbiotti, Maria A; Iozzo, Renato V (2017) Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis. J Biol Chem 292:5055-5069
Fried, Nathan T; Elliott, Melanie B; Oshinsky, Michael L (2017) The Role of Adenosine Signaling in Headache: A Review. Brain Sci 7:
Gubbiotti, Maria A; Neill, Thomas; Iozzo, Renato V (2017) A current view of perlecan in physiology and pathology: A mosaic of functions. Matrix Biol 57-58:285-298
Wang, Guangyu (2017) Mechanistic insight into the heme-independent interplay between iron and carbon monoxide in CFTR and Slo1 BKCa channels. Metallomics 9:634-645
Eisner, VerĂ³nica; Cupo, Ryan R; Gao, Erhe et al. (2017) Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity. Proc Natl Acad Sci U S A 114:E859-E868

Showing the most recent 10 out of 142 publications