Basic biomedical research on alcohol has undergone remarkable growth at the University of New Mexico (UNM) in the past ten years. Currently, five Department of Neurosciences faculty are principal investigators on one or more extramural grants for alcohol research. Three other department faculty have NIAAA research grants pending. Having reached a critical mass of funded investigators with a strong record of multidisciplinary research collaboration, the Alcohol Research Group is striving to take the next step by establishing mechanisms to support an Alcohol Research Training in Neurosciences (ARTN) program. If this NIAAA-sponsored training grant application is funded, the ARTN Program would use these funds to provide three years of support for four additional graduate students recruited into UNM's Biomedical Sciences Graduate Program. First year ARTN program trainees would complete one year of required and selected coursework and conduct three rotations in laboratories of ARTN program core or affiliated faculty. Second-year trainees would take upper level neuroscience graduate courses and prepare a dissertation proposal. Third-year trainees would begin their dissertation research with a core faculty member and would apply for an F-31 award to support the remainder of their predoctoral training experience. Drs. Perrone-Bizzozero (as PI), Allan, Caldwell, Valenzuela and Savage, all Department of Neurosciences faculty members, will comprise the ARTN program core faculty steering committee. Eleven other faculty at UNM will serve as affiliated faculty. The Department of Neurosciences has a long history of effective teaching and research interactions by a group of faculty with diverse backgrounds in research training. During the past four years, the department has hired three new junior faculty, renovated most of its laboratory space, established a two-year cycle of upper level neuroscience graduate courses, and doubled its research revenues. In support of this training grant application, the department will commit resources to cost-share faculty salary support, student tuition, fees and health insurance, stipend supplements, recruiting expenses and expenses associated with an annual retreat. In addition, the department and the School of Medicine will provide ARTN program trainees access to its core facilities, which include state-of-the-art equipment for use in the study of molecular neurobiology, functional genomics and proteomics, neuroimaging, neuroanatomy, electrophysiology, and behavioral neuroscience. The ARTN program will encourage its trainees to take full advantage of the diversity in the neuroscience community at UNM to undertake multidisciplinary research projects that will increase their potential to become successful alcohol research investigators in the future.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA014127-05
Application #
7267117
Study Section
Special Emphasis Panel (ZAA1-GG (01))
Program Officer
Grandison, Lindsey
Project Start
2003-08-08
Project End
2008-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
5
Fiscal Year
2007
Total Cost
$119,769
Indirect Cost
Name
University of New Mexico
Department
Biochemistry
Type
Schools of Medicine
DUNS #
868853094
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Oliver, R J; Brigman, J L; Bolognani, F et al. (2018) Neuronal RNA-binding protein HuD regulates addiction-related gene expression and behavior. Genes Brain Behav 17:e12454
Kenton, Johnny A; Castillo, Rebecca; Holmes, Andrew et al. (2018) Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm. Neurobiol Learn Mem 156:60-67
Bastle, R M; Oliver, R J; Gardiner, A S et al. (2018) In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens. Mol Psychiatry 23:434-443
Oliver, Robert J; Kenton, Johnny A; Stevens, Wennonah et al. (2018) Overexpression of neuronal RNA-binding protein HuD increases reward induced reinstatement of an instrumental response. Neurosci Lett 683:119-124
Harvey, Ryan E; Rutan, Stephanie A; Willey, Gabrielle R et al. (2018) Linear Self-Motion Cues Support the Spatial Distribution and Stability of Hippocampal Place Cells. Curr Biol 28:1803-1810.e5
Sanchez, Joshua J; Noor, Shahani; Davies, Suzy et al. (2017) Prenatal alcohol exposure is a risk factor for adult neuropathic pain via aberrant neuroimmune function. J Neuroinflammation 14:254
Marquardt, Kristin; Sigdel, Rahul; Brigman, Jonathan L (2017) Touch-screen visual reversal learning is mediated by value encoding and signal propagation in the orbitofrontal cortex. Neurobiol Learn Mem 139:179-188
Marquardt, Kristin; Brigman, Jonathan L (2016) The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models. Alcohol 51:1-15
Topper, Lauren A; Baculis, Brian C; Valenzuela, C Fernando (2015) Exposure of neonatal rats to alcohol has differential effects on neuroinflammation and neuronal survival in the cerebellum and hippocampus. J Neuroinflammation 12:160
Bird, Clark W; Candelaria-Cook, Felicha T; Magcalas, Christy M et al. (2015) Moderate prenatal alcohol exposure enhances GluN2B containing NMDA receptor binding and ifenprodil sensitivity in rat agranular insular cortex. PLoS One 10:e0118721

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