This is a competitive renewal application for an Alcohol Training Program in Neurosciences at the University of New Mexico (UNM-ARTN). This program is currently ending Year 4 of support. It has had a tremendously positive impact on graduate education at our institution and has increased visibility of alcohol research across campus. The program provides multidisciplinary training that includes molecular biological, biochemical, electrophysiological, imaging and behavioral techniques. The focus of the UNM-ARTN program is to provide training in alcohol neuroscience research. Our group has strengths in three areas of fetal alcohol spectrum disorder research: 1. Basic mechanisms involved in ethanol neuroteratogenesis;2. Biomarkers of prenatal alcohol exposure;and 3. Therapeutic interventions to ameliorate FASD-related cognitive deficits. In addition, we are investigating the short- and long-term effects of ethanol on mature neuronal circuits in different brain regions. Seven faculty members of the Department of Neurosciences (Allan, Caldwell, Cunninham, Perrone-Bizzozero, Savage, Valenzuela, Zhao) and one member of the Department of Psychology (Hamilton) will be directly involved in the program as core faculty. There have been extensive interactions among the eight members of the core faculty. This is evident by their record of joint publications, co-mentoring of trainees and collaborative grant applications. These individuals will train students from the Biomedical Sciences Graduate Program of the Health Sciences Center and students from the Cognition, Brain and Behavior Program of the Psychology Department. The program will support 4 students per year. In addition to the course requirements for each of these programs, predoctoral trainees will be required to complete specific courses (Neurobiology of Alcoholism;Developmental Neurotoxicology;Problem-based Bioethics, Scientific Writing), and participate in the Alcohol Research Journal Club. They will also be required to submit predoctoral NRSA applications. The program will be overseen by Drs. Valenzuela (Director) and Perrone-Bizzozero (Co-Director), an Executive Committee composed of members of the training faculty, and an external advisory committee. We will continue our efforts to recruit underrepresented minorities into the program. Our goal is to provide high quality graduate students with training that will prepare them for a successful future career in alcohol research relevance. This is a competitive renewal application for a program that will support training of graduate students for careers in alcohol neuroscience research. Alcohol is a major public health problem;it is responsible for a large number of illnesses, injuries and deaths in the United States.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA014127-07
Application #
7665577
Study Section
Special Emphasis Panel (ZAA1-HH (10))
Program Officer
Grandison, Lindsey
Project Start
2003-08-08
Project End
2013-07-31
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
7
Fiscal Year
2009
Total Cost
$61,850
Indirect Cost
Name
University of New Mexico
Department
Neurosciences
Type
Schools of Medicine
DUNS #
868853094
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Bastle, R M; Oliver, R J; Gardiner, A S et al. (2018) In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens. Mol Psychiatry 23:434-443
Oliver, Robert J; Kenton, Johnny A; Stevens, Wennonah et al. (2018) Overexpression of neuronal RNA-binding protein HuD increases reward induced reinstatement of an instrumental response. Neurosci Lett 683:119-124
Harvey, Ryan E; Rutan, Stephanie A; Willey, Gabrielle R et al. (2018) Linear Self-Motion Cues Support the Spatial Distribution and Stability of Hippocampal Place Cells. Curr Biol 28:1803-1810.e5
Oliver, R J; Brigman, J L; Bolognani, F et al. (2018) Neuronal RNA-binding protein HuD regulates addiction-related gene expression and behavior. Genes Brain Behav 17:e12454
Kenton, Johnny A; Castillo, Rebecca; Holmes, Andrew et al. (2018) Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm. Neurobiol Learn Mem 156:60-67
Sanchez, Joshua J; Noor, Shahani; Davies, Suzy et al. (2017) Prenatal alcohol exposure is a risk factor for adult neuropathic pain via aberrant neuroimmune function. J Neuroinflammation 14:254
Marquardt, Kristin; Sigdel, Rahul; Brigman, Jonathan L (2017) Touch-screen visual reversal learning is mediated by value encoding and signal propagation in the orbitofrontal cortex. Neurobiol Learn Mem 139:179-188
Marquardt, Kristin; Brigman, Jonathan L (2016) The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models. Alcohol 51:1-15
Topper, Lauren A; Baculis, Brian C; Valenzuela, C Fernando (2015) Exposure of neonatal rats to alcohol has differential effects on neuroinflammation and neuronal survival in the cerebellum and hippocampus. J Neuroinflammation 12:160
Bird, Clark W; Candelaria-Cook, Felicha T; Magcalas, Christy M et al. (2015) Moderate prenatal alcohol exposure enhances GluN2B containing NMDA receptor binding and ifenprodil sensitivity in rat agranular insular cortex. PLoS One 10:e0118721

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