Abstract

This renewal of """"""""Training in the Neurobiology and Endocrinology of Aging"""""""" proposes to support 8 pre-doctoral and 8 postdoctoral trainees under the direction of 25 tenure-track faculty from the School of Gerontology; the College of Letters, Arts, and Sciences; the School of Pharmacy; and the School of Medicine. Effort is given to increasing the recruitment of under-represented minorities. The training program is based on directed research in the laboratory; bimonthly chalk-talks; a new seminar course entitled: """"""""Recent advances in the neurobiology and endocrinology of aging""""""""; and instruction in the responsible conduct of research. Opportunities for human studies on aging, including ethnic differences in aging processes, are provided through the Alzheimer Disease Research Center and the Diabetes Research Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG000093-24
Application #
6926094
Study Section
Special Emphasis Panel (ZAG1-FAS-5 (J1))
Program Officer
Monjan, Andrew A
Project Start
1982-09-01
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
24
Fiscal Year
2005
Total Cost
$1
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
Other Domestic Higher Education
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Hasson, Rebecca E; Adam, Tanja C; Davis, Jaimie N et al. (2012) Randomized controlled trial to improve adiposity, inflammation, and insulin resistance in obese African-American and Latino youth. Obesity (Silver Spring) 20:811-8
Hasson, Rebecca E; Adam, Tanja C; Davis, Jaimie N et al. (2010) Ethnic differences in insulin action in obese African-American and Latino adolescents. J Clin Endocrinol Metab 95:4048-51
Finch, Caleb E; Morgan, Todd E; Longo, Valter D et al. (2010) Cell resilience in species life spans: a link to inflammation? Aging Cell 9:519-26
Yao, Jia; Irwin, Ronald W; Zhao, Liqin et al. (2009) Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 106:14670-5
Aguirre, Claudia C; Baudry, Michel (2009) Progesterone reverses 17beta-estradiol-mediated neuroprotection and BDNF induction in cultured hippocampal slices. Eur J Neurosci 29:447-54
Koebnick, C; Roberts, C K; Shaibi, G Q et al. (2008) Adiponectin and leptin are independently associated with insulin sensitivity, but not with insulin secretion or beta-cell function in overweight Hispanic adolescents. Horm Metab Res 40:708-12
Koebnick, C; Kelly, L A; Lane, C J et al. (2008) Combined association of maternal and paternal family history of diabetes with plasma leptin and adiponectin in overweight Hispanic children. Diabet Med 25:1043-8
Irwin, Ronald W; Yao, Jia; Hamilton, Ryan T et al. (2008) Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology 149:3167-75
Nilsen, Jon; Irwin, Ronald W; Gallaher, Timothy K et al. (2007) Estradiol in vivo regulation of brain mitochondrial proteome. J Neurosci 27:14069-77
Mathiyakom, Witaya; McNitt-Gray, Jill L; Wilcox, Rand R (2007) Regulation of angular impulse during two forward translating tasks. J Appl Biomech 23:149-61

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