This revised application outlines a comprehensive interdisciplinary program leading to specialized research, education and training in the neurobiology of aging. It is a continuation of a successful basic science training program that began in 1989 conducted by the Center for the Neurobiology of Aging at the University of Florida. The co-Directors of the grant are Ed Meyer, Ph.D. and Philip J. Scarpace, Ph.D., both of whom are successful investigators in this field with extensive training and administrative experience. The 12 training faculty (preceptors and directors) span 4 departments, the local Veterans Administration GRECC, and 2 colleges in the Health Sciences Center. Preceptors were chosen for their productivity in the neurobiology of aging, training backgrounds, and interactions with other preceptors at didactic and research levels. Research resources include well supplied and supported laboratories for each preceptor, numerous UF Core facilities, support from the Center for the Neurobiology of Aging, and additional stipend support from the Provost's office. Didactic facilities include well designed graduate curricula in the Interdisciplinary Program (IDP) of the College of Medicine and a required course entitled """"""""Neurobiology of Aging,"""""""" multiple seminar series covering topics in this area, and a large number of additional elective aging and neuroscience courses throughout departments at UF. Administrative support also includes a full time secretarial assistant and funds for trainee recruitment and travel. A new feature of this program involves establishing a nation-wide competition for a travel award for an advanced graduate student to present their work at the annual GSA meeting, followed by a visit to the University of Florida. This award, sponsored and funded by the Center for the Neurobiology of Aging, is expected to help our program to identify and recruit outstanding young researchers in the aging field, as well as increase the visibility of our program within the aging community. This training grant is expected to continue to facilitate the career development of young investigators based on our progress to date, including: 1) the successful filling of every training position over the past 15 years; 2) the overall research productivity of the fellows during their training interval; 3) the high fraction of trainees over the past 10 years who have remained in research, either as faculty members (9/25), on the academic path toward an independent research position (postdoctoral or graduate student level; 9/25), or in industry (7/25). ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
2T32AG000196-16A1
Application #
7233094
Study Section
Special Emphasis Panel (ZAG1-ZIJ-9 (J2))
Program Officer
Wise, Bradley C
Project Start
1989-09-01
Project End
2012-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
16
Fiscal Year
2007
Total Cost
$253,646
Indirect Cost
Name
University of Florida
Department
Pharmacology
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Whidden, Melissa A; Basgut, Bilgen; Kirichenko, Nataliya et al. (2016) Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats. J Exerc Nutrition Biochem 20:58-64
Gocmez, Semil S; Scarpace, Philip J; Whidden, Melissa A et al. (2016) Age Impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries. J Exerc Nutrition Biochem 20:41-8
Mitzelfelt, Jeremiah D; Carter, Christy S; Morgan, Drake (2014) Thermal sensitivity across ages and during chronic fentanyl administration in rats. Psychopharmacology (Berl) 231:75-84
Vasselli, Joseph R; Scarpace, Philip J; Harris, Ruth B S et al. (2013) Dietary components in the development of leptin resistance. Adv Nutr 4:164-75
Tumer, Nihal; Svetlov, Stanislav; Whidden, Melissa et al. (2013) Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla. Neurosci Lett 544:62-7
Scarpace, E T; Matheny, M; Strehler, K Y E et al. (2012) Simultaneous introduction of a novel high fat diet and wheel running induces anorexia. Physiol Behav 105:909-14
Williams, Dustin K; Peng, Can; Kimbrell, Matthew R et al. (2012) Intrinsically low open probability of ?7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures. Mol Pharmacol 82:746-59
Njie, eMalick G; Kantorovich, Svetlana; Astary, Garrett W et al. (2012) A preclinical assessment of neural stem cells as delivery vehicles for anti-amyloid therapeutics. PLoS One 7:e34097
Morgan, Drake; Mitzelfelt, Jeremiah D; Koerper, Lorraine M et al. (2012) Effects of morphine on thermal sensitivity in adult and aged rats. J Gerontol A Biol Sci Med Sci 67:705-13
Njie, Emalick G; Boelen, Ellen; Stassen, Frank R et al. (2012) Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function. Neurobiol Aging 33:195.e1-12

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