The research training program in """"""""Gerontology and Exercise Physiology"""""""" at University of Maryland Baltimore is mentored-based in an enriched academic environment with a multidisciplinary faculty and a strong curricula to teach trainees the skills to become independent investigators in the biology of exercise and metabolism research in aging. Training faculty are experienced, well-funded investigators studying the genetic, cellular, and molecular mechanisms by which exercise and diet affect CVD risk factors and diabetes, fat and muscle metabolism, cardiovascular and musculoskeletal function.
The aims are to mentor our trainees with an indepth research experience in the principles of clinical and basic laboratory investigations, genetics, epidemiology and biostatistics, to study the pathophysiologic mechanisms at the cellular, molecular, and genetic levels and then translate them to the whole body to understand the affects of exercise training and diet on metabolism, diabetes, and cardiovascular risk in older people. The goal is that by completion of the research training experience, these young investigators will have the expertise in clinical and molecular medical research, genetics and functional genomics and endocrine metabolism research, to perform independent clinical and basic investigations in gerontology. The major strengths of this training program are a well funded faculty with: 1) outstanding mentoring experience, 2) strong collaborations and interactions in aging, exercise, and metabolism research, 3) available grants to fund trainees in the conduct of biomedical research, and 4) well equipped laboratories and research facilities. The mentored training program includes basic training in the laboratory, didactic courses, lectures, research seminars, journal clubs, and training in the conduct of clinical research and ethical issues. The program directors receive guidance in research training from an NRSA advisory committee composed of senior faculty. Facilities include well-equipped human exercise physiology testing and training facilities, fully equipped clinical and basic laboratory space for the conduct of clinical investigation and biomedical research. Trainees have access to computers, research equipment, excellent libraries, and an extensive graduate curriculum to supplement their mentor-based clinical and basic research training in the biology of exercise and metabolism research in aging. We are confident that our environment will prepare trainees for academic careers to study the mechanisms at the cellular, molecular and genetic levels by which health promotion, disease prevention and rehabilitation strategies involving exercise and dietary interventions will improve the health of the elderly by reducing their risk factors for CVD and type 2 diabetes, and improving their functional capacity. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
2T32AG000219-11
Application #
6593165
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (J1))
Program Officer
Nayfield, Susan G
Project Start
1992-09-30
Project End
2008-04-30
Budget Start
2003-05-01
Budget End
2004-04-30
Support Year
11
Fiscal Year
2003
Total Cost
$206,364
Indirect Cost
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Addison, Odessa; Ryan, Alice S; Prior, Steven J et al. (2017) Changes in Function After a 6-Month Walking Intervention in Patients With Intermittent Claudication Who Are Obese or Nonobese. J Geriatr Phys Ther 40:190-196
Addison, Odessa; Inacio, Mario; Bair, Woei-Nan et al. (2017) Role of Hip Abductor Muscle Composition and Torque in Protective Stepping for Lateral Balance Recovery in Older Adults. Arch Phys Med Rehabil 98:1223-1228
Serra, M C; Ryan, A S; Goldberg, A P (2017) Reduced LPL and subcutaneous lipid storage capacity are associated with metabolic syndrome in postmenopausal women with obesity. Obes Sci Pract 3:106-114
Serra, M C; Ryan, A S (2016) Influence of Vitamin D and Parathyroid Hormone on Bone and Metabolic Risk in Women with Previous Gestational Diabetes. Horm Metab Res 48:497-502
Lodh, Sukanya; Hostelley, Timothy L; Leitch, Carmen C et al. (2016) Differential effects on ?-cell mass by disruption of Bardet-Biedl syndrome or Alstrom syndrome genes. Hum Mol Genet 25:57-68
Ehret, Georg B (see original citation for additional authors) (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet 48:1171-1184
Serra, Monica C; Goldberg, Andrew P; Ryan, Alice S (2016) Increased depression and metabolic risk in postmenopausal breast cancer survivors. Diabetol Metab Syndr 8:44
O'Hare, Elizabeth A; Yerges-Armstrong, Laura M; Perry, James A et al. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of ?-Cell Mass Deficits. Mol Endocrinol 30:429-45
Addison, Odessa; Steinbrenner, Gregory; Goldberg, Andrew P et al. (2015) Aging, Fitness, and Marathon Times in a 91 Year-old Man Who Competed in 627 Marathons. Br J Med Med Res 8:1074-1079
Peprah, Emmanuel; Xu, Huichun; Tekola-Ayele, Fasil et al. (2015) Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease. Public Health Genomics 18:40-51

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