Abstract

This proposal requests funds for a pre-doctoral training program in disease oriented basic neuroscience with an emphasis on aging and age-related neurological disorders. The program is designed to offer M.D./Ph.D. or Ph.D. student's rigorous and specialized training in the neurobiology of aging and age-related neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease and stroke. The Graduate Program in Neuroscience at Rush University is one of the few programs that offers training in disease oriented basic neuroscience; it is housed in the Department of Neurological Sciences, a department where a large number of basic scientists and clinicians work very closely together. Preceptors for the proposed predoctoral training program include nine basic scientists with well funded research programs and a long-standing commitment to aging research; their expertise ranges all the way from molecular and structural biology to electrophysiology and behavior. Additional teaching faculty include other basic scientists and clinicians in the Department of Neurological Sciences, as well as members of other divisions in the Medical Center. ? ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG000269-09
Application #
7228227
Study Section
Special Emphasis Panel (ZAG1-ZIJ-6 (J1))
Program Officer
Wise, Bradley C
Project Start
1999-05-01
Project End
2009-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
9
Fiscal Year
2007
Total Cost
$109,979
Indirect Cost

  Institution

Name
Rush University Medical Center
Department
Neurosciences
Type
Schools of Medicine
DUNS #
068610245
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Goldman, Jennifer G; Aggarwal, Neelum T; Schroeder, Cynthia D (2015) Mild cognitive impairment: an update in Parkinson's disease and lessons learned from Alzheimer's disease. Neurodegener Dis Manag 5:425-43
Corbett, Grant T; Gonzalez, Frank J; Pahan, Kalipada (2015) Activation of peroxisome proliferator-activated receptor ? stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A 112:8445-50
Kelley, Christy M; Powers, Brian E; Velazquez, Ramon et al. (2014) Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice. J Comp Neurol 522:1390-410
Kelley, Christy M; Powers, Brian E; Velazquez, Ramon et al. (2014) Sex differences in the cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease. Brain Pathol 24:33-44
Corbett, Grant T; Buss, Eric W (2014) Non-neuronal cells exacerbate ?-amyloid aggregation in the aged brain. J Neurosci 34:9825-7
Velazquez, Ramon; Ash, Jessica A; Powers, Brian E et al. (2013) Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 58:92-101
Li, Xin; Kroin, Jeffrey S; Kc, Ranjan et al. (2013) Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints. J Bone Miner Res 28:2512-22
Menon, Vilas; Musial, Timothy F; Liu, Annie et al. (2013) Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites. Neuron 80:1451-63
Dougherty, Kelly A; Nicholson, Daniel A; Diaz, Laurea et al. (2013) Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. J Neurophysiol 109:1940-53
Corbett, Grant T; Roy, Avik; Pahan, Kalipada (2013) Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy. J Biol Chem 288:8299-312

Showing the most recent 10 out of 23 publications