Abstract

This application from the University of Alabama at Birmingham requests continued support for a pre- and post-doctoral training program in immunology. The program provides basic research training in lymphocyte differentiation, complement and cytokines, mucosal immunology, HIV and microbial pathogenesis, antigen receptor signaling, immunogenetics, structure and function of B cell and T cell receptors, and neurovirology. Program faculty that are members of clinical departments provide an interface between clinical and basic research. Research opportunities directly related to human disease are in the areas of: autoimmunity and immune complex diseases, vaccine development, neoplastic disease, immunodeficiencies, and microbial and parasitic pathogenesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007051-23
Application #
2855900
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1976-07-01
Project End
2001-12-31
Budget Start
1999-01-01
Budget End
1999-12-31
Support Year
23
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Boppana, Sushma; Goepfert, Paul (2018) Understanding the CD8 T-cell response in natural HIV control. F1000Res 7:
Gibson, Sara A; Yang, Wei; Yan, Zhaoqi et al. (2018) CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1. J Immunol 201:383-392
Owusu, Benjamin Y; Zimmerman, Kurt A; Murphy-Ullrich, Joanne E (2018) The role of the endoplasmic reticulum protein calreticulin in mediating TGF-?-stimulated extracellular matrix production in fibrotic disease. J Cell Commun Signal 12:289-299
DiToro, Daniel; Winstead, Colleen J; Pham, Duy et al. (2018) Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science 361:
Yan, Zhaoqi; Gibson, Sara A; Buckley, Jessica A et al. (2018) Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases. Clin Immunol 189:4-13
Ergen, Elizabeth N; Yusuf, Nabiha (2018) Inhibition of interleukin-12 and/or interleukin-23 for the treatment of psoriasis: What is the evidence for an effect on malignancy? Exp Dermatol 27:737-747
Hamilton, Jennie A; Wu, Qi; Yang, PingAr et al. (2018) Cutting Edge: Intracellular IFN-? and Distinct Type I IFN Expression Patterns in Circulating Systemic Lupus Erythematosus B Cells. J Immunol 201:2203-2208
Pham, Duy (2017) A Method to In Vitro Differentiate Th9 Cells from Mouse Naïve CD4+ T Cells. Methods Mol Biol 1585:51-57
Seleme, Maria C; Kosmac, Kate; Jonjic, Stipan et al. (2017) Tumor Necrosis Factor Alpha-Induced Recruitment of Inflammatory Mononuclear Cells Leads to Inflammation and Altered Brain Development in Murine Cytomegalovirus-Infected Newborn Mice. J Virol 91:
Rowse, Amber L; Gibson, Sara A; Meares, Gordon P et al. (2017) Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells. J Neurooncol 132:219-229

Showing the most recent 10 out of 245 publications