The purpose of this program continues to be the training of physician and postgraduate scientists for careers as investigators in fields of research relating to viral pathogenesis, immunity and the prevention and therapy of virus induced diseases. The trainees are exposed to multi-disciplinary research laboratories in several departments which are headed by established investigators whose careers focus on these research areas. The research performed by the faculty sponsors include the study of viral nucleic acid and protein synthesis in the virus infected cell, the expression of viral antigens and peptides on the surface of infected cells, the structure-function relationships of those antigens, the varied and complex immune responses induced by the virus and the virus infected cells, and the subsequent pathogenesis, immunopathology and disease in the viral infected host. The program is integrated so that clinical investigator trainees have contact with investigators working at the molecular level while postdoctoral non- clinical trainees are exposed to and participate in clinical research relating to viral diseases. The physician post-doctoral trainees participate in several formal courses in the graduate school which are directly relevant to this training and all trainees attend and present their research in a number of ongoing seminars. Trainees become equipped with the scientific background, experimental techniques, and critical judgement necessary for the development of successful research careers. The faculty investigators are closely involved with the efforts of each other's laboratories through scheduled research seminars and through collective efforts. This program provides highly trained and creative clinical and basic scientists committed to research careers in the field of viral pathogenesis and immunity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007272-16
Application #
2876543
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Sager, Polly R
Project Start
1989-09-01
Project End
2004-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Colbert, Jeff D; Farfán-Arribas, Diego J; Rock, Kenneth L (2013) Substrate-induced protein stabilization reveals a predominant contribution from mature proteins to peptides presented on MHC class I. J Immunol 191:5410-9
Oestreich, Kenneth J; Weinmann, Amy S (2012) T-bet employs diverse regulatory mechanisms to repress transcription. Trends Immunol 33:78-83
Meriin, Anatoli B; Mense, Martin; Colbert, Jeff D et al. (2012) A novel approach to recovery of function of mutant proteins by slowing down translation. J Biol Chem 287:34264-72
Oestreich, Kenneth J; Mohn, Sarah E; Weinmann, Amy S (2012) Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol 13:405-11
Oestreich, Kenneth J; Weinmann, Amy S (2012) Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat Rev Immunol 12:799-804
Oestreich, Kenneth J; Weinmann, Amy S (2012) Encoding stability versus flexibility: lessons learned from examining epigenetics in T helper cell differentiation. Curr Top Microbiol Immunol 356:145-64
Oestreich, Kenneth J; Weinmann, Amy S (2012) Transcriptional mechanisms that regulate T helper 1 cell differentiation. Curr Opin Immunol 24:191-5
Oestreich, Kenneth J; Huang, Albert C; Weinmann, Amy S (2011) The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med 208:1001-13
Smith, Heidi L; Monath, Thomas P; Pazoles, Pamela et al. (2011) Development of antigen-specific memory CD8+ T cells following live-attenuated chimeric West Nile virus vaccination. J Infect Dis 203:513-22
Miller, Sara A; Weinmann, Amy S (2010) Molecular mechanisms by which T-bet regulates T-helper cell commitment. Immunol Rev 238:233-46

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