The overall goal of this competing renewal application (Years 16-20) is to train postdoctoral physician fellows for successful research careers in academic infectious diseases. Support is again requested for 3 fellows/year for 5 years. During the current funding cycle, 6 fellows were appointed to our Research Training Program (2/year), including 2 from underrepresented minorities. Two fellows have completed the Training Program and are in academic or public health positions, and the 4 other appointees remain in training (2 in their 3rd year and 1 each in their 2nd and 1st year of training). Collectively, these trainees have published 20 papers (16 first authored) in peer-reviewed journals. ? ? Each year, we have carefully assessed the recruitment efforts and performance of the trainees and mentors in our Program and have implemented important changes to strengthen it. We will offer training in the 3 areas of greatest mentoring strength in infectious diseases at the University of Pittsburgh: HIV/AIDS, Molecular Epidemiology and Microbiology, and Sexually Transmitted Diseases. There is a critical need for well-trained physician investigators in each of these areas. The mentoring faculty, consisting of 6 MD and 9 PhD scientists from the Schools of Medicine and Public Health, have exemplary records of research accomplishment, funding and training of postdoctoral fellows. ? ? Physicians who have completed the first clinical year of infectious disease fellowship will be eligible for the Research Training Program. Appointees are selected by the Program Executive Committee, consisting of the PI and senior mentoring faculty. Appointees develop a three-year research Training Plan with their mentor for approval by the Executive Committee. The performance of the trainees is carefully reviewed by the mentor (weekly), the PI (quarterly), and the Executive Committee (biannually). The latter occurs at Fellows Research in Progress Meeting (July and January), during which all trainees present their work and are challenged to defend their research findings and plans. Issues related to responsible conduct of research are discussed throughout the Training Program. ? ? The goal of the Program is for each trainee to develop expertise in an area of infectious disease research that will serve as the foundation for a successful investigative career. Our Program will increase the capacity for research that is highly relevant to the NIAID mission. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007333-17
Application #
7121194
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
Project Start
1988-09-01
Project End
2010-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
17
Fiscal Year
2006
Total Cost
$127,999
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Cillo, Anthony R; Hilldorfer, Benedict B; Lalama, Christina M et al. (2015) Virologic and immunologic effects of adding maraviroc to suppressive antiretroviral therapy in individuals with suboptimal CD4+ T-cell recovery. AIDS 29:2121-9
Vadnerkar, Aniket; Toyoda, Yoshiya; Crespo, Maria et al. (2011) Age-specific complications among lung transplant recipients 60 years and older. J Heart Lung Transplant 30:273-81
Vadnerkar, Aniket; Clancy, Cornelius J; Celik, Umit et al. (2010) Impact of mold infections in explanted lungs on outcomes of lung transplantation. Transplantation 89:253-60
Endimiani, Andrea; Doi, Yohei; Bethel, Christopher R et al. (2010) Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2. Biochemistry 49:1014-23
Doi, Y; Paterson, D L; Egea, P et al. (2010) Extended-spectrum and CMY-type beta-lactamase-producing Escherichia coli in clinical samples and retail meat from Pittsburgh, USA and Seville, Spain. Clin Microbiol Infect 16:33-8
Vadnerkar, Aniket; Nguyen, M Hong; Mitsani, Dimitra et al. (2010) Voriconazole exposure and geographic location are independent risk factors for squamous cell carcinoma of the skin among lung transplant recipients. J Heart Lung Transplant 29:1240-4
McKinnon, John E; Mellors, John W; Swindells, Susan (2009) Simplification strategies to reduce antiretroviral drug exposure: progress and prospects. Antivir Ther 14:1-12
Wilkin, Timothy J; McKinnon, John E; DiRienzo, A Gregory et al. (2009) Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy: final 48-week clinical and virologic outcomes. J Infect Dis 199:866-71
Doi, Yohei; Paterson, David L; Adams-Haduch, Jennifer M et al. (2009) Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase. Antimicrob Agents Chemother 53:3159-61
Curry, Scott R; Marsh, Jane W; Shutt, Kathleen A et al. (2009) High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital. Clin Infect Dis 48:425-9

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