The primary purpose of this training grant program is the development of scientific leaders for careers in HIV/AIDS research. The current expanding epidemic of HIV infection demands commitment of investigators to the training of a new generation of leaders in research. It is anticipated that graduates of this postdoctoral program will follow careers in research related to AIDS. This program will provide in depth laboratory experience in a specific research area of virology, immunology, molecular biology, oncology, epidemiology molecular genetics, or molecular therapeutics to selected candidates. Trainees will be MDs after completion of their clinical residencies and specialty training or PhDs and ScDs from an appropriate basic science program. Criteria for selection will include prior training record, aptitude for research and commitment to research careers. All applicants will be selected by a Program Steering Committee, and six will be selected annually. Particular emphasis will be given to the recruitment of minorities and others underrepresented in AIDS research, e.g., women, individuals with disabilities, and those from disadvantaged backgrounds. The basic elements of the program are: 1) in depth research training through laboratory investigation of a specific problem in a particular area related to AIDS under a senior investigator;2) a didactic program consisting of appropriately chosen specific courses which will advance the trainee's knowledge;3) frequent exposure to seminars, workshops, and colloquia related to AIDS;4) regular review of progress by individual Progress Evaluation Committees and the Program Steering Committee. The primary training facilities consist of well equipped research laboratories at Harvard Medical School, Harvard School of Public Health, Massachusetts General Hospital, Beth Israel-Deaconess Medical Center, Brigham and Women's Hospital, the Immune Disease Institute, Dana-Farber Cancer Institute, the Ragon Institute and the New England Primate Research Center. Senior and Junior faculty at each of these institutions are on the faculty of this grant, and they represent a variety of disciplines. The faculty collaborates with one another on AIDS research and will collaborate in directing this training program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
7T32AI007387-25
Application #
8672580
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
Project Start
1990-08-01
Project End
2015-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
25
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Lim, So-Yon; Osuna, Christa E; Hraber, Peter T et al. (2018) TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy. Sci Transl Med 10:
Chowdhury, Fatema Z; Ouyang, Zhengyu; Buzon, Maria et al. (2018) Metabolic pathway activation distinguishes transcriptional signatures of CD8+ T cells from HIV-1 elite controllers. AIDS 32:2669-2677
McCluskey, Suzanne M; Lee, Guinevere Q; Kamelian, Kimia et al. (2018) Increasing Prevalence of HIV Pretreatment Drug Resistance in Women But Not Men in Rural Uganda During 2005-2013. AIDS Patient Care STDS 32:257-264
AbdelRazek, Mahmoud A; Gutierrez, Jose; Mampre, David et al. (2018) Intravenous Thrombolysis for Stroke and Presumed Stroke in Human Immunodeficiency Virus-Infected Adults: A Retrospective, Multicenter US Study. Stroke 49:228-231
McCluskey, Suzanne M; Boum 2nd, Yap; Musinguzi, Nicholas et al. (2017) Brief Report: Appraising Viral Load Thresholds and Adherence Support Recommendations in the World Health Organization Guidelines for Detection and Management of Virologic Failure. J Acquir Immune Defic Syndr 76:183-187
Lee, Guinevere Q; McCluskey, Suzanne; Boum 2nd, Yap et al. (2017) Brief Report: Should Abacavir Be a First-Line Alternative for Adults With HIV in Sub-Saharan Africa? J Acquir Immune Defic Syndr 76:188-192
Penaloza MacMaster, Pablo; Shields, Jennifer L; Alayo, Quazim A et al. (2017) Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. Vaccine 35:1-9
Best, Katharine; Guedj, Jeremie; Madelain, Vincent et al. (2017) Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies. Proc Natl Acad Sci U S A 114:8847-8852
Viganò, Selena; Negrón, Jordi J; Tse, Samantha et al. (2017) HLA-G+ HIV-1-specific CD8+ T cells are associated with HIV-1 immune control. AIDS 31:207-212
Bhattacharyya, Mitra; Madden, Patrick; Henning, Nathan et al. (2017) Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection. Immunology 152:328-343

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