The immunologist of tomorrow must appreciate both basic and clinical immunology to effectively utilize modern tools of research in the pursuit of new knowledge about immune mediated and infectious diseases and their pathogenesis as well as for development of new vaccines and therapies against immune-mediated diseases. Training the scientist and the physician-scientist in immunology and its relationship to infectious diseases as well as to other related disciplines such as pathology, biochemistry, cell biology, and biotechnology will be crucial for the future of immunological sciences. To facilitate the distribution of knowledge in the field of immunology, the Immunology Training Program goals are to provide fundamental and research training to 4 predoctoral and 1 postdoctoral fellows with an immunology faculty of 25 preceptors including 7 new faculty. The program is unique in that it encompasses faculty from the University of Oklahoma Health Sciences Center (OUHSC) and the Oklahoma Medical Research Foundation (OMRF) as well as its strong focus on microbial as well as host immunology. The participating training faculty are particularly strong in the 4 disciplines emphasized in the Immunology Training Program, which include 1) Responses to Pathogens, 2) Lymphocyte Development and Signaling, 3) Inflammation and 4) Autoimmunity. The faculty preceptors have interacted on the OUHSC campus for years, forming a network that is particularly suited to train a cohesive group of pre and postdoctoral fellows in molecular immunology. The program recruits students and fellows from national and international sources, has strong NIH funded research programs, and has new faculty and facilities all of which foster an atmosphere of excellence in training. The predoctoral students are eligible for the training program after completion of their lab rotations and qualifying exam. The Immunology Training Program will provide in-depth enrichment in the 4 sub-disciplines to the pre and postdoctoral trainees. Postdoctoral fellows are strongly encouraged to take coursework and to mentor predoctoral students to enhance their immunology experience. The Immunology Training Program advisory and selection committee selects the pre and postdoctoral trainees and act in an advisory capacity. Since the beginning of the program, September 1, 2001, the objectives of the program are being met to provide excellence in research, and immunology course work as well as retreats and the Immunology Journal Club class which has been important for teaching current state of the art immunology to the trainees and faculty. Yearly retreats and the journal club class have been effective in bringing pre and postdoctoral fellows together with the immunology training faculty in an environment that fosters excellence. Our program has been and will continue to be important to prepare trainees for future careers in immunology.

Public Health Relevance

The Immunology Training Program in Oklahoma will recruit and train students pursuing a PhD and/or MD degree (predoctoral trainees) or individuals who already have the PhD and/or MD degree(postdoctoral trainees) to perform medical and basic research in immunology. For example, trainees might study how infections affect the immune system such as in the study of immune responses to vaccines or how infections may lead to autoimmune diseases or how the immune system develops or responds to infections. Training in research laboratories of nationally and internationally recognized scientists along with a curriculum in immunology classes, retreats and national meetings will provide crucial training for the future immunologists in the United States.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007633-17
Application #
9706714
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
2001-06-01
Project End
2023-05-31
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
17
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
DeVette, Christa I; Andreatta, Massimo; Bardet, Wilfried et al. (2018) NetH2pan: A Computational Tool to Guide MHC Peptide Prediction on Murine Tumors. Cancer Immunol Res 6:636-644
Quinn, James L; Kumar, Gaurav; Agasing, Agnieshka et al. (2018) Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation. Front Immunol 9:382
Dumas, Eric K; Garman, Lori; Cuthbertson, Hannah et al. (2017) Lethal factor antibodies contribute to lethal toxin neutralization in recipients of anthrax vaccine precipitated. Vaccine 35:3416-3422
Guthmiller, Jenna J; Graham, Amy C; Zander, Ryan A et al. (2017) Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. J Immunol 198:617-622
Zander, Ryan A; Vijay, Rahul; Pack, Angela D et al. (2017) Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity. Cell Rep 21:1839-1852
Griffith, Gina L; Kasus-Jacobi, Anne; Pereira, H Anne (2017) Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections. Adv Wound Care (New Rochelle) 6:175-190
Menendez, Chandra M; Carr, Daniel J J (2017) Herpes simplex virus-1 infects the olfactory bulb shortly following ocular infection and exhibits a long-term inflammatory profile in the form of effector and HSV-1-specific T cells. J Neuroinflammation 14:124
Menendez, Chandra M; Carr, Daniel J J (2017) Defining nervous system susceptibility during acute and latent herpes simplex virus-1 infection. J Neuroimmunol 308:43-49
Li, He; Reksten, Tove Ragna; Ice, John A et al. (2017) Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons. PLoS Genet 13:e1006820
Slight-Webb, Samantha; Lu, Rufei; Ritterhouse, Lauren L et al. (2016) Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity. Arthritis Rheumatol 68:2492-502

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