This is a new NRSA application to support two postdoctoral trainees per year for five years This award will substantially increase the ability of talented trainees to exploit outstanding opportunities to pursue research training in infectious diseases at Baylor College of Medicine. At this time, no NRSA exists within Baylor College of Medicine or the Texas Medical Center to pursue clinical research training in non-AIDS infections. Yet, there is increasing need for trained professionals capable of performing clinically based research directed at treatment and prevention of non-AIDS infections that threaten the health of US citizens, including age-old scourges such as infectious gastroenteritis and pneumonia and new threats posed by bioterrorism. Superb training opportunities exist at Baylor College of Medicine in a number of areas, including biodefense. Participating projects with a strong record of federal funding and training experience include: 1) Innate Immunity and Nosocomial Infections; 2) Parasitic Infections; 3) Viral and Bacterial Gastroenteritis; 4) Viral Oncogenesis; 5) Acute Respiratory Pathogens; 6) Vaccine Evaluations; 7) Tuberculosis; 8) Helicobacter pylori Infection; and 9) Prostheses Infections. Total grant support in 2002 for the specific centers and programs participating in this NRSA Program is $19,769,825. The structure of the Program for Research Training in Infections and Immunity will contain three components that represent general training tracks that can be pursued by trainees: 1) laboratory-based clinical research; 2) clinical research trials; and 3) clinical epidemiology. All trainees will be encouraged to participate in the Clinical Scientist Training Program at Baylor College of Medicine and obtain their Masters Degree in Clinical Investigation. Those pursuing the clinical epidemiology track may opt for a MPH Degree at the University of Texas-Houston School of Public Health. The Adult Infectious Diseases Training Program at Baylor College of Medicine has shown it can attract highly qualified postdoctoral trainees, half of them women and close to a quarter underrepresented minorities, and point them in the direction of future infectious diseases clinical research. In the past two years, this program has produced graduates who have successfully pursued each of the three training pathways proposed. Altogether, these four individuals have published 26 original peer-reviewed manuscripts and have been awarded several prestigious grants and career development awards, totaling $1,862,500. This recent track record is offered as evidence in support of the request for two postdoctoral trainees per year.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI055413-04
Application #
7100910
Study Section
Special Emphasis Panel (ZAI1-YL-M (M1))
Program Officer
Mcsweegan, Edward
Project Start
2003-08-01
Project End
2008-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
4
Fiscal Year
2006
Total Cost
$125,980
Indirect Cost
Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Weatherhead, Jill E; Porter, Paul; Coffey, Amy et al. (2018) Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice. Infect Immun 86:
Rajan, Anubama; Vela, Lucy; Zeng, Xi-Lei et al. (2018) Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal Enteroids. MBio 9:
Poole, Nina M; Rajan, Anubama; Maresso, Anthony W (2018) Human Intestinal Enteroids for the Study of Bacterial Adherence, Invasion, and Translocation. Curr Protoc Microbiol 50:e55
Cortes-Penfield, Nicolas; Oliver, Nora T; Hunter, Andrew et al. (2018) Daptomycin and combination daptomycin-ceftaroline as salvage therapy for persistent methicillin-resistant Staphylococcus aureus bacteremia. Infect Dis (Lond) 50:643-647
Cortes-Penfield, Nicolas W; Ramani, Sasirekha; Estes, Mary K et al. (2017) Prospects and Challenges in the Development of a Norovirus Vaccine. Clin Ther 39:1537-1549
Weatherhead, Jill E; Hotez, Peter J; Mejia, Rojelio (2017) The Global State of Helminth Control and Elimination in Children. Pediatr Clin North Am 64:867-877
Weatherhead, Jill; Cortés, Andrea Arévalo; Sandoval, Carlos et al. (2017) Comparison of Cytokine Responses in Ecuadorian Children Infected with Giardia, Ascaris, or Both Parasites. Am J Trop Med Hyg 96:1394-1399
Cortes-Penfield, Nicolas W; Trautner, Barbara W; Jump, Robin L P (2017) Urinary Tract Infection and Asymptomatic Bacteriuria in Older Adults. Infect Dis Clin North Am 31:673-688
McKenna, Megan L; McAtee, Shannon; Bryan, Patricia E et al. (2017) Human Intestinal Parasite Burden and Poor Sanitation in Rural Alabama. Am J Trop Med Hyg 97:1623-1628
Poole, Nina M; Green, Sabrina I; Rajan, Anubama et al. (2017) Role for FimH in Extraintestinal Pathogenic Escherichia coli Invasion and Translocation through the Intestinal Epithelium. Infect Immun 85:

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