The goal of the Immunology and Infectious Disease Training Program (IIDTP) at Indiana University School of Medicine is to develop diverse, multi-faceted scientists capable of responding to the nation's health and educational needs in the areas of host immunity and infection. Advanced knowledge of the immune system and infectious agents is essential given their impact on an increasing number of issues in human health including metabolic, vascular and cardiac diseases, aging, neural disorders, and cancer. This renewal application seeks continued support for years 16-20 of the IIDTP with three primary components of the training program. The first component is support of three pre-doctoral fellows, the second is support of two postdoctoral fellows, and the final component is the support of four short-term trainees (medical students) for summer research experiences, all within an interactive, multi-disciplinary medical center environment. Institutional support for the IIDTP is considerable and includes financial support for trainee education and program direction, administrative support, and state of the art facilities for basic and translational research. The IIDTP unites thirty-one faculty in a highly developed infrastructure that includes training opportunities for the development of multiple skills needed for a successful career in science. Strengths of the program include the highly collaborative research of the faculty, an established program for mentoring at all levels, an extensive track record of relevant, quality publications from mentors and trainees, program mentors' sustained acquisition of extramural research funding, and successful placement of trainees in relevant careers including academics, medicine, government, and industry. Comprehensive training is offered through didactic courses including bioethics, research seminars and conferences, program-specific journal clubs and meetings, grant and career workshops, and face-to-face faculty mentoring. The program is directed with careful consideration of trainee progress and mentor success. Altogether, this active and successful training program remains poised to prepare trainees for central roles in health and education-related professions.

Public Health Relevance

This T32 renewal application supports Immunology and Infectious Diseases Training for predoctoral students and postdoctoral fellows, and short-term research experiences for medical students at Indiana University. This is a unique training program in the state and provides the training infrastructure for thirty-one program faculty and over 100 trainees.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI060519-17
Application #
9959305
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Coomes, Stephanie
Project Start
2004-09-01
Project End
2024-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
17
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Pediatrics
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Varberg, Joseph M; LaFavers, Kaice A; Arrizabalaga, Gustavo et al. (2018) Characterization of Plasmodium Atg3-Atg8 Interaction Inhibitors Identifies Novel Alternative Mechanisms of Action in Toxoplasma gondii. Antimicrob Agents Chemother 62:
Brandt, Stephanie L; Putnam, Nicole E; Cassat, James E et al. (2018) Innate Immunity to Staphylococcus aureus: Evolving Paradigms in Soft Tissue and Invasive Infections. J Immunol 200:3871-3880
Kono, Tatsuyoshi; Tong, Xin; Taleb, Solaema et al. (2018) Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic ?-Cell. Diabetes 67:2293-2304
Brandt, Stephanie L; Wang, Sue; Dejani, Naiara N et al. (2018) Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice. JCI Insight 3:
Bagaitkar, Juhi; Huang, Jing; Zeng, Melody Yue et al. (2018) NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood 131:2367-2378
Long, Quanxin; Yan, Ran; Hu, Jieli et al. (2017) The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. PLoS Pathog 13:e1006784
Brandt, Stephanie L; Serezani, C Henrique (2017) Too much of a good thing: How modulating LTB4 actions restore host defense in homeostasis or disease. Semin Immunol 33:37-43
Ulrich, Benjamin J; Verdan, Felipe Fortino; McKenzie, Andrew N J et al. (2017) STAT3 Activation Impairs the Stability of Th9 Cells. J Immunol 198:2302-2309
Justis, Anna V; Hansen, Bryan; Beare, Paul A et al. (2017) Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1L. Cell Microbiol 19:
Culleton, Sara P; Kanginakudru, Sriramana; DeSmet, Marsha et al. (2017) Phosphorylation of the Bovine Papillomavirus E2 Protein on Tyrosine Regulates Its Transcription and Replication Functions. J Virol 91:

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