The Harvard Medical School Department of Dermatology training grant has been active for more than 35 years, and over that period of time has trained many of the leaders in dermatology in the nation. Dr. Thomas Kupper has served as Principal Investigator of this T32 since 2000. Although there is a single Harvard residency training program, there are now three Harvard Dermatology appointing departments: the Beth Israel Deaconess Hospital, Brigham and Women's Hospital, and Massachusetts General Hospital. An executive committee comprised of the chairs of each of these departments oversees the residency program, and provides advice to Dr. Kupper with regard to the T32 grant. The training grant has two overarching goals. The first is to identify, recruit, and support dermatologist physician scientists interested in a career in biomedical research. While such candidates most often come from Harvard's Dermatology Residency, trainees from other residencies are eligible as well. The second overarching goal is to support the development of outstanding PhD scientists who are interested in a research career in investigative dermatology and related fields. We have achieved these goals over the past 4.5 years of the training grant, training a nearly equal mix of physician scientists and PhD scientists. Considering the past decade of the training grant, 92% of the physician scientists who matriculated still remain in academic medicine, and 88% of PhD scientists remain in academia or in the biotechnology sector. This group of 31 trainees has authored 220 peer reviewed manuscripts since 2005, and the mean impact factor of these publications is an impressive 9.23. Over the past 15 years, graduates of the program include a Department Chair (Dr. Qureshi), a Division Chief (Dr. Aires), an internationally known immunodermatologist (Dr. Clark), and many other academic faculty, several of whom hold NIH funding. For the next funding cycle, we have recruited an outstanding External Advisory Board consisting of eminent academic dermatologists and scientists, who will assist with choosing candidates. It remains our conviction that Training Grant support for young biomedical scientists interested in skin disease research has never been more critical to their careers, and by extension, the long term survival of academic investigative dermatology

Public Health Relevance

At least two years of mentorship and training in research approaches and techniques are absolutely essential as graduates of dermatology training programs or PhD programs transition from student to independent biomedical scientists. The Harvard Dermatology Training grant provides this support, partnering the most promising trainees with accomplished and supportive research mentors who will sponsor their work in their laboratories. We wish to continue to build on the extraordinary success that this program has achieved over the last 40 years, in training the best and the brightest biomedical scientists of tomorrow.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32AR007098-42
Application #
9072756
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Cibotti, Ricardo
Project Start
1980-09-01
Project End
2021-04-30
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
42
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
Erlich, Tal H; Fisher, David E (2018) Pathways in melanoma development. G Ital Dermatol Venereol 153:68-76
Gehad, Ahmed; Teague, Jessica E; Matos, Tiago R et al. (2018) A primary role for human central memory cells in tissue immunosurveillance. Blood Adv 2:292-298
Choo, Min-Kyung; Kraft, Stefan; Missero, Caterina et al. (2018) The protein kinase p38? destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential. Sci Signal 11:
de Masson, Adele; O'Malley, John T; Elco, Christopher P et al. (2018) High-throughput sequencing of the T cell receptor ? gene identifies aggressive early-stage mycosis fungoides. Sci Transl Med 10:
Nirschl, Christopher J; Suárez-Fariñas, Mayte; Izar, Benjamin et al. (2017) IFN?-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell 170:127-141.e15
Choo, Min-Kyung; Sano, Yasuyo; Kim, Changhoon et al. (2017) TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. J Exp Med 214:1297-1311
Matos, Tiago R; O'Malley, John T; Lowry, Elizabeth L et al. (2017) Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing ?? T cell clones. J Clin Invest 127:4031-4041
Hayakawa, Morisada; Hayakawa, Hiroko; Petrova, Tsvetana et al. (2017) Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem 292:1762-1772
Lee, Byung Cheon; Lee, Sang-Goo; Choo, Min-Kyung et al. (2017) Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo. Sci Rep 7:5119
Semeere, Aggrey; Freeman, Esther; Wenger, Megan et al. (2017) Updating vital status by tracking in the community among patients with epidemic Kaposi sarcoma who are lost to follow-up in sub-Saharan Africa. BMC Cancer 17:611

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