This is a competing renewal application of a training grant currently in its 24th year of funding. The overall goal of this proposal is to train postdoctoral M.D. and Ph.D. fellows for academic careers in investigational dermatology. Its first objective is to provide laboratory training for dermatologically trained physicians. Its second objective is to train Ph.D. basic scientists in laboratory based investigative dermatology. Its third objective is to train dermatologically trained physicians in clinical and translational research. Physician trainees will have completed a minimum of two clinical years of dermatology residency, while basic scientist candidates must possess the Ph.D. degree. Trainees will commit to a minimum of two years of research training, which will occur under the supervision of one of eight (or, in some cases, two of eight) primary preceptors. Laboratory based fellows (M.D. and Ph.D.) will learn to formulate hypotheses and to design, perform, and analyze experiments, utilizing a multidisciplinary approach that emphasizes the use of human skin tissue as an experimental system. M.D. trainees in clinical/translational research will acquire proficiency in hypothesis driven clinical research design and methods and in statistical analysis of data, while gaining an appreciation of the basic science knowledge underlying their clinical observations and interventions. To maximize multidisciplinary training, primary preceptors have been selected not only for their teaching skills, but also for their collaborative abilities and the span of disciplines defining their research. In addition to mandatory participation in selected departmental didactic activities, introductory and advanced courses in clinical research methods and a molecular biology course for clinician scientists will be available for trainees through the Medical School and the School of Public Health. Also, training in the responsible conduct of research will be provided at the departmental and University wide levels. In order to attract more dermatologists into academic careers, they propose to add two year fellowships in cutaneous oncology and appearance based dermatology, and to expand the traditional clinical research base in skin pharmacology to encompass a wider spectrum of interventions, notably those involving ultraviolet light. They are also changing the resident selection procedure in order to identify and attract NRSA eligible M.D.s with strong research potential. Finally, they have created a Web site for dissemination of detailed information about the program to all potential trainees, including those belonging to underrepresented minorities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007197-29
Application #
6888290
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Baker, Carl
Project Start
1977-07-01
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
29
Fiscal Year
2005
Total Cost
$174,743
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Dermatology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Tsoi, Lam C; Yang, Jingjing; Liang, Yun et al. (2018) Transcriptional determinants of individualized inflammatory responses at anatomically separate sites. J Allergy Clin Immunol 141:805-808
Cole, Megan A; Quan, Taihao; Voorhees, John J et al. (2018) Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging. J Cell Commun Signal 12:35-43
Swindell, William R; Beamer, Maria A; Sarkar, Mrinal K et al. (2018) RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature. Front Immunol 9:80
Swindell, William R; Sarkar, Mrinal K; Liang, Yun et al. (2017) RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin. Sci Rep 7:18045
Klein, Rachel Herndon; Lin, Ziguang; Hopkin, Amelia Soto et al. (2017) GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states. PLoS Genet 13:e1006745
Worthen, Christal A; RittiƩ, Laure; Fisher, Gary J (2017) Mechanical Deformation of Cultured Cells with Hydrogels. Methods Mol Biol 1627:245-251
Swindell, William R; Michaels, Kellie A; Sutter, Andrew J et al. (2017) Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis. Genome Med 9:24
Liang, Yun; Xing, Xianying; Beamer, Maria A et al. (2017) Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders. J Allergy Clin Immunol 139:1217-1227
Liang, Yun; Sarkar, Mrinal K; Tsoi, Lam C et al. (2017) Psoriasis: a mixed autoimmune and autoinflammatory disease. Curr Opin Immunol 49:1-8
Liang, Yun; Kahlenberg, J Michelle; Gudjonsson, Johann E (2017) A vestigial pathway for sex differences in immune regulation. Cell Mol Immunol 14:578-580

Showing the most recent 10 out of 54 publications