(taken from application) The basic philosophy of our training program in dermatology is to provide the most outstanding experience at the postdoctoral level in basic and clinical research relating to the skin. The strength of this program resides in its faculty, all of whom have extensive NIH grant support, many of whom are among the world's scientific leaders in their fields, and who possess fundamental expertise in diverse biological problems ranging from matrix metalloproteinases, connective tissue structural proteins, cell-fate choices in development, desmosome structure, genetics, endothelial cell biology, macrophage function, tumor biology, and mechanisms of gene expression. The areas under investigation in our laboratories require diverse scientific approaches involving recombinant DNA technology, the development of 'knockout' and transgenic mice, gene regulation and sequencing, cell culture, enzymology, immunohistochemistry, in situ hybridization, and protein chemistry (protein structure, peptide synthesis, and crystallography), enabling a trainee to acquire the breadth of knowledge to pursue the best biologic problem in the most creative manner. Furthermore, several of our trainees elect to perform their postdoctoral fellowships in non-dermatology research laboratories in the basic science departments of Washington University School of Medicine. This provides access for such individuals to an even larger group of world-class scientists. These trainees work at the forefront of a basic problem with eventual applications to dermatology. There are weekly research seminars and journal clubs presented by our department as well as seminars offered several times a week by the Division of Biological and Biomedical Sciences of the medical school, which add to the trainees' educational experience. In general, the program is of 3 years duration and is aimed at training promising physicians and Ph.D.'s for careers in academic dermatology. Support is requested for 5 postdoctoral trainees and one predoctoral trainee. Candidates are selected from our clinical training program and/or from applicants applying directly to our research program. Criteria for selection include high academic performance, letters of recommendation, curriculum vitae, and most of all, a strong commitment to an academic career in dermatology. This program is intended to continue the training of our specialty's future basic scientists and academicians with unwavering commitment and relentless vigor.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007284-24
Application #
6374786
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Moshell, Alan N
Project Start
1978-07-01
Project End
2003-04-30
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
24
Fiscal Year
2001
Total Cost
$79,103
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Favazza, Christopher P; Cornelius, Lynn A; Wang, Lihong V (2011) In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin. J Biomed Opt 16:026004
Favazza, Christopher P; Jassim, Omar; Cornelius, Lynn A et al. (2011) In vivo photoacoustic microscopy of human cutaneous microvasculature and a nevus. J Biomed Opt 16:016015
Avirutnan, Panisadee; Hauhart, Richard E; Somnuke, Pawit et al. (2011) Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation. J Immunol 187:424-33
Tryon, Robert C; Higdon, Charles W; Johnson, Stephen L (2011) Lineage relationship of direct-developing melanocytes and melanocyte stem cells in the zebrafish. PLoS One 6:e21010
Jarad, George; Miner, Jeffrey H (2009) The Pax3-Cre transgene exhibits a rostrocaudal gradient of expression in the skeletal muscle lineage. Genesis 47:1-6
Hsu, Tony M; Kwok, Pui-Yan (2003) Homogeneous primer extension assay with fluorescence polarization detection. Methods Mol Biol 212:177-87
Hsu, T M; Chen, X; Duan, S et al. (2001) Universal SNP genotyping assay with fluorescence polarization detection. Biotechniques 31:560, 562, 564-8, passim
Hsu, T M; Law, S M; Duan, S et al. (2001) Genotyping single-nucleotide polymorphisms by the invader assay with dual-color fluorescence polarization detection. Clin Chem 47:1373-7
Karelina, T V; Bannikov, G A; Eisen, A Z (2000) Basement membrane zone remodeling during appendageal development in human fetal skin. The absence of type VII collagen is associated with gelatinase-A (MMP2) activity. J Invest Dermatol 114:371-5
Marth, G T; Korf, I; Yandell, M D et al. (1999) A general approach to single-nucleotide polymorphism discovery. Nat Genet 23:452-6

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