We propose to continue to provide postdoctoral training in mineral and skeletal homeostasis to four trainees per year. Trainees will be selected from among those who have a doctoral degree, principally on the basis of their promise for a career in biomedical research in mineral and skeletal metabolism, but also giving preference to members of under- represented minority groups. Training will, as in previous years, be conducted principally by mentoring in the laboratories of faculty members of this training grant. These faculty members represent the Departments of Biochemistry (in the School of Dental Medicine), Clinical Epidemiology and Biostatistics, Medicine (Division of Endocrinology, Diabetes and Metabolism), Orthopedics (Division of Molecular Orthopedics and Metabolic Bone Disease), Pediatrics (Section or Nutrition), and Radiology. Members of the faculty collaborate with the others often, so trainees are frequently exposed to more than on discipline in the course of training. Each trainee is expected to have at least two years of laboratory training. Coursework in basic science areas is available though the University's Graduate Biomedical Studies Program and in clinical epidemiology and biostatistics though the Department of Clinical Epidemiology and Biostatistics. Trainees are expected to participate in the seminar series of their respective departments and to present their work before the faculty of the training grant.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007481-19
Application #
6511772
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Sharrock, William J
Project Start
1984-09-30
Project End
2004-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
19
Fiscal Year
2002
Total Cost
$143,338
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Benito, Maria; Vasilic, Branimir; Wehrli, Felix W et al. (2005) Effect of testosterone replacement on trabecular architecture in hypogonadal men. J Bone Miner Res 20:1785-91
Benito, Maria; Gomberg, Bryon; Wehrli, Felix W et al. (2003) Deterioration of trabecular architecture in hypogonadal men. J Clin Endocrinol Metab 88:1497-502
Song, Y H; Naumova, A K; Liebhaber, S A et al. (1999) Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster. Genome Res 9:581-7
Haddad, J G (1997) Osteoporosis in men. Rev Rhum Engl Ed 64:81S-83S
Liu, C; Wallace, K; Shi, C et al. (1996) Post-transcriptional stimulation of transforming growth factor beta 1 mRNA by TGF-beta 1 treatment of transformed human osteoblasts. J Bone Miner Res 11:211-17
Tang, W X; Bazaraa, H M; Magiera, H et al. (1996) Electrophoretic mobility shift assay identifies vitamin D binding protein (Gc-globulin) in human, rat, and mouse sera. Anal Biochem 237:245-51
Hu, Z Y; Blazar, P E; Haddad, J G (1995) Preventing actin interference in immunonephelometric measurements of vitamin D-binding protein (Gc-globulin). Clin Chem 41:623-5
Davis, K D; Lazar, M A (1992) Selective antagonism of thyroid hormone action by retinoic acid. J Biol Chem 267:3185-9
Haddad, J G; Hu, Y Z; Kowalski, M A et al. (1992) Identification of the sterol- and actin-binding domains of plasma vitamin D binding protein (Gc-globulin). Biochemistry 31:7174-81
Mc Leod, J F; Kowalski, M A; Haddad Jr, J G (1989) Interactions among serum vitamin D binding protein, monomeric actin, profilin, and profilactin. J Biol Chem 264:1260-7

Showing the most recent 10 out of 11 publications