This continuation of an established program emphasizes the techniques and concepts of cell and molecular biology, genetics, computational biology, musculoskeletal (limb) regenerative medicine and fundamental studies of immunology relevant to rheumatic, autoimmune and musculoskeletal diseases. Original population- based clinical research employs rigorous methodological design and statistical analysis. Support is requested for 6 postdoctoral trainees with an M.D., a Ph.D., or both, and for 1 predoctoral (Ph.D candidate) trainee. The faculty are carefully selected and perform research in areas of: I) Basic Biology including, 1) Adaptive Immunity (B and T Cell Biology), 2) Innate immunity, 3) Musculoskeletal (Limb) Regeneration and 4) Computational Biology, and II) Translational and Clinical Research including 1) Animal Models of Rheumatic and Musculoskeletal disorders, 2) Human Immunology and Genetics of Rheumatic Disease and 3) Patient-Centered Research in the Epidemiology and Outcomes of Rheumatic and Orthopedic Diseases. While the primary strength of the program resides in the direct and individual nature of the interaction in the laboratory between each trainee and the responsible faculty member(s), substantial didactic experiences, the medical school and university environments, along with a series of structured activities foster interactions and supplement training. Trainees audit semester courses at Harvard Medical School in their field of basic science, while population science investigators obtain an MPH or a similar degree at the Harvard School of Public Health. Postdoctoral trainees in a combined clinical and research training program join this program after completing their clinical training. Graduate students join the program only after completing course work and are in Harvard Ph.D Programs in Biomedical and Biological Sciences including (1) Immunology and 2) Bioinformatics and Integrative Genomics. The program is hosted in the Division of Rheumatology, Immunology and Allergy at Brigham and Women?s Hospital. Importantly, approximately 40% of faculty are part of the program but located in other divisions, departments and Harvard Medical School affiliated Institutions and are selected for their relevance to the program goals and their outstanding scientific and training expertise. Besides Brigham and Women?s Hospital Departments of Medicine, Orthopedics and Neurology, they include faculty at 1) the Broad Institute of Harvard and MIT, 2) Boston Children?s Hospital, 3) Massachusetts General Hospital, 4) Harvard Medical School Departments of Immunology, Biomedical Informatics, and Genetics, 5) Harvard University Department of Stem Cell and Regenerative medicine, and 6) the Harvard School of Public Health. The program goal is to provide an ongoing pipeline of highly trained and expert investigators prepared for and focused in rheumatic and related musculoskeletal disease research.

Public Health Relevance

The Division of Rheumatology, Immunology and Allergy at Brigham and Women?s Hospital and this training grant vehicle provide the core that integrates basic and translational investigators across Harvard-affiliated institutions working in areas of basic biology, and translational and population sciences relevant to and focused in musculoskeletal and autoimmune rheumatic disease. Its goal is to provide an ongoing pipeline of select, highly trained and expert investigators prepared for and focused in rheumatic disease research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32AR007530-36
Application #
9935220
Study Section
Special Emphasis Panel (ZAR1)
Program Officer
Marquitz, Aron
Project Start
1985-07-01
Project End
2025-04-30
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
36
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Sparks, Jeffrey A; Barbhaiya, Medha; Tedeschi, Sara K et al. (2018) Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women. Clin Rheumatol :
Tedeschi, Sara K; Bathon, Joan M; Giles, Jon T et al. (2018) Relationship Between Fish Consumption and Disease Activity in Rheumatoid Arthritis. Arthritis Care Res (Hoboken) 70:327-332
LaMarche, Nelson M; Kohlgruber, Ayano C; Brenner, Michael B (2018) Innate T Cells Govern Adipose Tissue Biology. J Immunol 201:1827-1834
Sparks, Jeffrey A; Chang, Shun-Chiao; Nguyen, Uyen-Sa D T et al. (2018) Smoking Behavior Changes in the Early Rheumatoid Arthritis Period and Risk of Mortality During Thirty-Six Years of Prospective Followup. Arthritis Care Res (Hoboken) 70:19-29
Sparks, Jeffrey A; Chang, Shun-Chiao; Nguyen, Uyen-Sa et al. (2018) Weight Change During the Early Rheumatoid Arthritis Period and Risk of Subsequent Mortality in Women With Rheumatoid Arthritis and Matched Comparators. Arthritis Rheumatol 70:18-29
Tedeschi, Sara K; Cui, Jing; Arkema, Elizabeth V et al. (2017) Elevated BMI and antibodies to citrullinated proteins interact to increase rheumatoid arthritis risk and shorten time to diagnosis: A nested case-control study of women in the Nurses' Health Studies. Semin Arthritis Rheum 46:692-698
Rao, Deepak A; Gurish, Michael F; Marshall, Jennifer L et al. (2017) Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature 542:110-114
Barbhaiya, Medha; Lu, Bing; Sparks, Jeffrey A et al. (2017) Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts. Arthritis Care Res (Hoboken) 69:384-392
Tedeschi, Sara K; Stone, Richard M; Helfgott, Simon M (2017) Calcium Pyrophosphate Crystal Inflammatory Arthritis (Pseudogout) with Myelodysplastic Syndrome: A New Paraneoplastic Syndrome? J Rheumatol 44:1101-1102
Tedeschi, Sara K; Guan, Hongshu; Fine, Alexander et al. (2016) Organ-specific systemic lupus erythematosus activity during pregnancy is associated with adverse pregnancy outcomes. Clin Rheumatol 35:1725-32

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