(Taken from the applicant's) This program provides interdisciplinary training in muscle biology for pre- and postdoctoral students. The program emphasizes the functional properties of skeletal, cardiac and smooth muscle. The 18 primary faculty members are from 4 departments at the University of Maryland School of Medicine, Baltimore, and the 2 Baltimore units of the University of Maryland Biotechnology Institute, with affiliates from the College of Engineering, University of Maryland Baltimore County. Reflecting this diversity of faculty backgrounds, the training opportunities cover a wide range and include: the molecular biological determinants of muscle cytoskeleton and matrix, biophysical and physiological analysis of the function of individual muscle cells, biomechanical properties of whole muscles and muscular organs, and the relationship of each of these approaches to muscle disease. The faculty work in the areas of calcium control of muscle function and muscle cytoskeletal and matrix. The students will receive training in these and a variety of related areas, including molecular and functional control of muscle gene expression, with emphasis on the use of several complementary techniques to approach each question under investigation. The major aspects of the didactic training consists of two interdisciplinary courses on muscle already offered by program faculty. They propose 4 predoctoral and 5 postdoctoral trainees for the first and second renewal year of the program, and then a steady state of 5 pre- and 6 postdoctoral trainees in the third through fifth years. Entering predoctoral trainees will have a background in biology, chemistry and/or physics, excellent GRE scores, research experience and strong letters of recommendation. Incoming postdoctoral trainees will have completed a solid Ph.D. thesis and have strong letters of recommendation. The application has significant and substantial scientific merit. Support is recommended for the five years, with a reduction in the budget, with a rating of outstanding.
| Banks, Quinton; Pratt, Stephen Joseph Paul; Iyer, Shama Rajan et al. (2018) Optical Recording of Action Potential Initiation and Propagation in Mouse Skeletal Muscle Fibers. Biophys J 115:2127-2140 |
| Collier, Alyssa F; Gumerson, Jessica; Lehtimäki, Kimmo et al. (2018) Effect of Ibuprofen on Skeletal Muscle of Dysferlin-Null Mice. J Pharmacol Exp Ther 364:409-419 |
| Ackermann, Maegen A; Shriver, Marey; Perry, Nicole A et al. (2018) Correction: Obscurins: Goliaths and Davids Take over Non-Muscle Tissues. PLoS One 13:e0190842 |
| Melville, Zephan; Aligholizadeh, Ehson; McKnight, Laura E et al. (2017) X-ray crystal structure of human calcium-bound S100A1. Acta Crystallogr F Struct Biol Commun 73:215-221 |
| Valencia, Ana P; Iyer, Shama R; Spangenburg, Espen E et al. (2017) Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear. BMC Musculoskelet Disord 18:436 |
| Hernández-Ochoa, Erick O; Banks, Quinton; Schneider, Martin F (2017) Acute Elevated Glucose Promotes Abnormal Action Potential-Induced Ca2+ Transients in Cultured Skeletal Muscle Fibers. J Diabetes Res 2017:1509048 |
| Desmond, Patrick F; Labuza, Amanda; Muriel, Joaquin et al. (2017) Interactions between small ankyrin 1 and sarcolipin coordinately regulate activity of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1). J Biol Chem 292:10961-10972 |
| Bittle, Gregory J; Kaushal, Sunjay (2017) Recreating the inferior vena cava with a patient-specific biodegradable conduit. J Thorac Cardiovasc Surg 153:933 |
| Robison, Patrick; Sussan, Thomas E; Chen, Hegang et al. (2017) Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD. Muscle Nerve 56:282-291 |
| Iyer, Shama R; Shah, Sameer B; Valencia, Ana P et al. (2017) Altered nuclear dynamics in MDX myofibers. J Appl Physiol (1985) 122:470-481 |
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