? This training grant proposal seeks support to prepare individuals (MD, MD/PhD, or PhD) for a career in biomedical science as it relates to pediatric and adult rheumatology. The program is based in a large Division of Rheumatology (Pediatric), with several center grants (P30, P60, PO1) and NIH-funded investigators with the participation of an enlarging Division of Rheumatology (Adult) that also has strong NIH funding. The Pediatric Division, including its related clinic, is part of Cincinnati Children's Hospital Medical Center (CCHMC) and The Children's Hospital Research Foundation (TCHRF), as well as part of the University of Cincinnati College of Medicine (UCCOM) with its clinical and biomedical science departments. The Adult Division is part of the Department of Medicine of UCCOM and has strong ties to the Pediatric Division and to immunobiology researchers at CCHMC and UCCOM. The primary faculty advisors come not only from divisions within the Department of Pediatrics (Rheumatology, Allergy/Immunology, Experimental Hematology, Hematology/Oncology, Human Genetics, Immunobiology, Informatics, Molecular Immunology, and Psychology) and the Department of Medicine (Immunology and Infectious Disease) but also from the Departments of Environmental Health, and Pathology, and cover broad areas of expertise. These include immunobiology, genomics and bioinformatics, gene expression, molecular and developmental biology, gene therapy, stem cell biology, epidemiologist and biostatistics, and musculoskeletal biomechanics. In addition to continued expansion in pediatric rheumatology, CCHMC, UCCOM, and TCHRF have also seen considerable growth during the present five-year cycle of this training grant, particularly in immunobiology, experimental hematology, and bioinformatics. The program is well supported by core facilities as well as by academic courses, including a mandatory course in medical ethics. Other available courses include immunobiology, molecular genetics, and epidemiology and biostatistics. A new interdepartmental Immunobiology Graduate Program (MS and PhD) that is centered at CCHMC complements existing programs in Epidemiology and Biostatistics, and Education in the UCCOM. It is believed that this rheumatology program provides unique resources and will continue to enlarge the pool of individuals with a career interest in biomedical science as it relates to the subspecialties, a pool that is far too small to meet the requirements of the next decades as molecular medicine is increasingly applied in the clinic. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32AR007594-11
Application #
6894195
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Serrate-Sztein, Susana
Project Start
1995-07-01
Project End
2010-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
11
Fiscal Year
2005
Total Cost
$310,279
Indirect Cost
Name
Children's Hospital Med Ctr (Cincinnati)
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Sherwin, Catherine M T; Ngamprasertwong, Pornswan; Sadhasivam, Senthilkumar et al. (2014) Utilization of optimal study design for maternal and fetal sheep propofol pharmacokinetics study: a preliminary study. Curr Clin Pharmacol 9:64-9
Sherwin, Catherine M T; Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi et al. (2012) Development of population PK model with enterohepatic circulation for mycophenolic acid in patients with childhood-onset systemic lupus erythematosus. Br J Clin Pharmacol 73:727-40
Sherwin, Catherine M T; SaldaƱa, Shannon N; Bies, Robert R et al. (2012) Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents. Ther Drug Monit 34:535-44
Divanovic, Senad; Sawtell, Nancy M; Trompette, Aurelien et al. (2012) Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis 205:152-61
Mina, Rina; Melson, Paula; Powell, Stephanie et al. (2011) Effectiveness of dexamethasone iontophoresis for temporomandibular joint involvement in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken) 63:1511-6
Sherwin, Catherine M T; Ding, Lili; Kaplan, Jennifer et al. (2011) Optimal study design for pioglitazone in septic pediatric patients. J Pharmacokinet Pharmacodyn 38:433-47
Merhar, Stephanie L; Schibler, Kurt R; Sherwin, Catherine M et al. (2011) Pharmacokinetics of levetiracetam in neonates with seizures. J Pediatr 159:152-154.e3
Sherwin, Catherine M T; Fukuda, Tsuyoshi; Brunner, Hermine I et al. (2011) The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet 50:1-24
Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Wiers, Kristina et al. (2011) Pharmacokinetics and pharmacodynamics of mycophenolic acid and their relation to response to therapy of childhood-onset systemic lupus erythematosus. Semin Arthritis Rheum 40:307-13
Sagcal-Gironella, Anna Carmela P; Sherwin, Catherine M T; Tirona, Rommel G et al. (2011) Pharmacokinetics of prednisolone at steady state in young patients with systemic lupus erythematosus on prednisone therapy: an open-label, single-dose study. Clin Ther 33:1524-36

Showing the most recent 10 out of 16 publications