This application requests a renewal of funding for a training program in Investigative Dermatology at Columbia University, College of Physicians and Surgeons. The program is designed to produce independent investigators capable of designing and executing programs of excellence in dermatological research, both basic and clinically-oriented. This program rests on a foundation of well-funded research in the biology of skin diseases that includes 15 investigators with diverse areas of expertise, and $11,937,586 of annual direct costs from the National Institutes of Health. The participating faculty have research programs that include direct dermatological applications, and many have collaborative relationships with each other and within the University. Seven trainers are within the Department of Dermatology and eight other are from outside departments. The participating faculty also has strong training records for both pre-doctoral and postdoctoral candidates. State of the art technology is being used by all investigators to study some of the most complex problems in investigative dermatology at the mechanistic level. The training program has two specific aims: first, to give trainees a broad perspective on current knowledge and the major questions facing investigative dermatology; second to offer a wide choice of research training opportunities in investigative dermatology, using a variety of model systems, that will allow the development of a hypothesis-driven, mechanistically oriented research program suited to the individual trainee. The participating investigators are qualified to provide training in the different aspects of cutaneous biology and have well-developed research programs. Trainees will be selected on the basis of academic excellence, investigative ability, and commitment to a career in investigative dermatology. Selection will be made by a steering committee that will also monitor their progress. Interactions between investigators and trainees will be fostered during weekly and monthly research meetings where both trainers and trainees will present the results of experiments. While training in the Department of Dermatology, trainees will be enriched by the milieu of the College of Physicians & Surgeons, Columbia University. Finally, the research training experience of chosen candidates will include instruction in the responsible conduct of research as well as written and oral presentation of their work. In summary, they have a goal to capitalize on the strengths of the funded investigators in the Department of Dermatology, as well as the University, to provide trainees with a mentorship experience that is likely to lead to a career in investigative dermatology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007605-09
Application #
7090631
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Baker, Carl
Project Start
1997-05-30
Project End
2008-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
9
Fiscal Year
2006
Total Cost
$150,644
Indirect Cost
Name
Columbia University (N.Y.)
Department
Dermatology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Scotti, Marina M; Swanson, Maurice S (2016) RNA mis-splicing in disease. Nat Rev Genet 17:19-32
Liu, Liang; Kim, Hyunmi; Casta, Alex et al. (2014) Hairless is a histone H3K9 demethylase. FASEB J 28:1534-42
DeStefano, Gina M; Fantauzzo, Katherine A; Petukhova, Lynn et al. (2013) Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis. Proc Natl Acad Sci U S A 110:7790-5
Kurban, M; Wajid, M; Shimomura, Y et al. (2013) Mutations in LPAR6/P2RY5 and LIPH are associated with woolly hair and/or hypotrichosis. J Eur Acad Dermatol Venereol 27:545-9
Luke, Courtney T; Casta, Alexandre; Kim, Hyunmi et al. (2013) Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis. Exp Dermatol 22:644-9
Casta, Alexandre; Kim, Hyunmi; Luke, Courtney T et al. (2012) Hairless and NF?B form a positive feedback loop after UVB and TNF? stimulation. Photochem Photobiol 88:1173-83
Kim, Hyunmi; Casta, Alexandre; Tang, Xiuwei et al. (2012) Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling. PLoS One 7:e39691
Fantauzzo, Katherine A; Christiano, Angela M (2012) Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. Development 139:203-14
Fantauzzo, Katherine A; Kurban, Mazen; Levy, Brynn et al. (2012) Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis. PLoS Genet 8:e1003002
Kiuru, Maija; Kurban, Mazen; Itoh, Munenari et al. (2011) Hereditary leukonychia, or porcelain nails, resulting from mutations in PLCD1. Am J Hum Genet 88:839-44

Showing the most recent 10 out of 15 publications