Viruses are significant cause of cancer in normal humans and are an even more common cause of cancer in immune deficient humans such as organ transplant recipients or HIV infected people. Furthermore, analyses of the way viruses alter cell growth has frequently led to the delineation of novel pathways of cell growth control and oncogenicity. This Program enables the training of 2 to 3 pre- and 5 post-doctoral trainees each year in the laboratories of the 20 faculty members working in Viral Oncology at Harvard University. The research objectives of these laboratories include (1) mechanisms by which RNA tumor viruses get into cells (2) mechanisms by which small DNA tumor viruses including human papillomaviruses alter cell growth and cause cervical cancer (4) mechanisms by which viruses alter cell signal transduction, transcription, cell cycle regulation, and cell survival and the role of these processes in normal and tumor cell growth. Trainees are recruited by the Virology and Biological and Biomedical Science Programs and enter the program because of their interest in viral oncology. Pre-doctoral students pursue 3 semesters of course work in molecular biology, genetics, cell biology, virology, and immunology while engaged in laboratory research training in viral oncology. Thereafter, they are fully engaged in mentored thesis research. Post-doctoral fellows engage full time in mentored research training research training. Pre- and post-doctoral students also participate in seminars, journal clubs, and research conferences including viral oncology and oncology research conferences. Trainees are jointly mentored by their principal research trainer and by other program faculty. On completion of their thesis research pre-doctoral students will be prepared for post-doctoral training and post-doctoral students will be prepared for independent research in viral oncology and related disciplines.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009031-27
Application #
6512276
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
1986-07-01
Project End
2004-05-31
Budget Start
2002-06-17
Budget End
2003-05-31
Support Year
27
Fiscal Year
2002
Total Cost
$248,763
Indirect Cost
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
de Wispelaere, Melissanne; LaCroix, Amy J; Yang, Priscilla L (2013) The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol 87:7367-81
Spangle, Jennifer M; Munger, Karl (2013) The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species. PLoS Pathog 9:e1003237
Spangle, Jennifer M; Ghosh-Choudhury, Nayana; Munger, Karl (2012) Activation of cap-dependent translation by mucosal human papillomavirus E6 proteins is dependent on the integrity of the LXXLL binding motif. J Virol 86:7466-72
Vetter, Michael L; Rodgers, Mary A; Patricelli, Matthew P et al. (2012) Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection. ACS Chem Biol 7:2019-26
Gewurz, Benjamin E; Towfic, Fadi; Mar, Jessica C et al. (2012) Genome-wide siRNA screen for mediators of NF-?B activation. Proc Natl Acad Sci U S A 109:2467-72
Gheuens, Sarah; Bord, Evelyn; Kesari, Santosh et al. (2011) Role of CD4+ and CD8+ T-cell responses against JC virus in the outcome of patients with progressive multifocal leukoencephalopathy (PML) and PML with immune reconstitution inflammatory syndrome. J Virol 85:7256-63
Gewurz, Benjamin E; Mar, Jessica C; Padi, Megha et al. (2011) Canonical NF-kappaB activation is essential for Epstein-Barr virus latent membrane protein 1 TES2/CTAR2 gene regulation. J Virol 85:6764-73
Gheuens, Sarah; Fellay, Jacques; Goldstein, David B et al. (2010) Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy. J Neurovirol 16:41-7
Gheuens, Sarah; Pierone, Gerald; Peeters, Patrick et al. (2010) Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression. J Neurol Neurosurg Psychiatry 81:247-54
Spangle, Jennifer M; Münger, Karl (2010) The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. J Virol 84:9398-407

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