Support is requested for continuation of the Carcinogenesis Training Program at the University of California, Irvine. This program, administered by the UCI Cancer Research Institute, is entering its 21st year and is a broad-based training program in basic cancer-related research, encompassing faculty from the School of Biological Sciences and from basic and clinical departments in the College of Medicine. There are thirty training faculty, eight predoctoral, and four postdoctoral positions requested. Twenty four faculty have funded research grants that meet the NC referral guidelines. Faculty research concentrations are in cell transformation and tumorigenesis; growth factors and cell signaling; cancer genetics; and experimental therapeutics. Predoctoral student are recruited through a joint graduate program in the five basic sciences departments. Predoctorals are typically supported for three years, and postdoctorals for two years. Trainees typically take research positions in academia, research institutions, or industry following their training. Features of this training program include (in addition to laboratory research) a course Clinical Cancer for """"""""Basic Scientists"""""""", a yearly course of the Carcinogenesis Training Program, an extensive series of national meetings, and regular multidisciplinary retreats and at the graduate level a concentration in cancer biology. The UCI Cancer Program (of which the Cancer Research Institute is the basic science arm) is now an NCI-designated Cancer center. This has enhanced the possibilities of translation training for this program. In this revised application two important changes have been effected. First, additions and deletions to the training faculty have sharpened the cancer focus of the training program. Second, a Cancer Biology concentration for the joint graduate program has been established. This substantially addresses concerns expressed in the previous review.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009054-25
Application #
6172490
Study Section
Cancer Research Manpower and Education Review Committee (CRME)
Program Officer
Gorelic, Lester S
Project Start
1980-07-01
Project End
2001-04-30
Budget Start
2000-05-01
Budget End
2001-04-30
Support Year
25
Fiscal Year
2000
Total Cost
$269,902
Indirect Cost
Name
University of California Irvine
Department
Internal Medicine/Medicine
Type
Organized Research Units
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Guerrero-Juarez, Christian F; Astrowski, Aliaksandr A; Murad, Rabi et al. (2018) Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis. J Invest Dermatol 138:1409-1419
Gotesman, Moran; Vo, Thanh-Trang T; Herzog, Lee-Or et al. (2018) mTOR inhibition enhances efficacy of dasatinib in ABL-rearranged Ph-like B-ALL. Oncotarget 9:6562-6571
Finicle, Brendan T; Ramirez, Manuel U; Liu, Gang et al. (2018) Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6. J Cell Sci 131:
Lee, J Scott; Roberts, Andrew; Juarez, Dennis et al. (2018) Statins enhance efficacy of venetoclax in blood cancers. Sci Transl Med 10:
Lee, Jennifer K; Enciso, Germán A; Boassa, Daniela et al. (2018) Replication-dependent size reduction precedes differentiation in Chlamydia trachomatis. Nat Commun 9:45
Thompson, Jordan M; Alvarez, Alejandro; Singha, Monika K et al. (2018) Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism. Mol Cancer Ther 17:1781-1792
Batabyal, Dipanwita; Richards, Logan S; Poulos, Thomas L (2017) Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics. J Am Chem Soc 139:13193-13199
Plikus, Maksim V; Guerrero-Juarez, Christian F; Ito, Mayumi et al. (2017) Regeneration of fat cells from myofibroblasts during wound healing. Science 355:748-752
McCracken, A N; McMonigle, R J; Tessier, J et al. (2017) Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia 31:669-677
Britton, Joshua; Dyer, Rebekah P; Majumdar, Sudipta et al. (2017) Ten-Minute Protein Purification and Surface Tethering for Continuous-Flow Biocatalysis. Angew Chem Int Ed Engl 56:2296-2301

Showing the most recent 10 out of 230 publications