This application is for the renewal of grant 5T32CA00911038 to support the training of predoctoral students and postdoctoral fellows in the fundamental biochemical, molecular, and cellular processes that ultimately give rise to the alterations characteristic of neoplastic transformation. Training is provided primarily by faculty from the Department of Biochemistry and Molecular Biology of the Johns Hopkins Bloomberg School of Public Health and the Sidney Kimmel Comprehensive Cancer Center of the Johns Hopkins Medical Institutions. The recruitment of nineteen new faculty members in recent years, the implementation of major revisions to the curriculum, and the introduction of individualized development plans will provide all trainees continued access to cutting edge instruction and research training opportunities in wellfunded and productive laboratories, and the knowledge to respond to the new and rapidly evolving research environment. Going forward, the Program requests support for seven predoctoral and three postdoctoral trainees per year. Trainees are required to attend and participate in a cancerfocused seminar series, a weekly journal club, a monthly research colloquium and related events that enhance their reasoning skills as bench scientists, their oral and written presentation skills, and their ability to work in a team settingand eventually lead. Predoctoral trainees are admitted to the Program after they have demonstrated a strong academic and laboratory rotation record in their first year of training and have selected a thesis dissertation project with a clear relevance to cancer. Outstanding postdoctoral candidates with a strong and substantiated interest in the pursuit of cancer biology are recruited to this Program. Major research themes with relevance to the cancer problem include: cell division, cell differentiation, and cell death; cellular remodeling and associated regulatory circuits; transcriptional, post-transcriptional and epigenetic regulation of gene expression; chromosomes, genome biology and maintenance of genome integrity; protein quality control mechanisms; stem cell biology and the role of microenvironments; inflammation and immune responses? chemical biology; and biomarkers. In the past this program has attracted talented young trainees, most of whom have remained in science and many of whom have achieved distinction in cancer biology. The proposed program will continue to bring trainees into the field and equip them for productive careers in cancer research.

Public Health Relevance

Cancer remains a major cause of mortality and morbidity in spite of significant advances in our understanding of its causes and progression. This program will train the next generation of successful independent scientists who will possess the outstanding knowledge, research and leadership skills that are necessary to continue fostering progress towards improving the prevention, early detection, and treatment of cancer, and to capitalize on new opportunities afforded by recent progress in biology and medicine.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
3T32CA009110-39A1S1
Application #
9404526
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Perkins, Susan N
Project Start
1975-06-30
Project End
2021-07-31
Budget Start
2016-08-10
Budget End
2017-07-31
Support Year
39
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Biochemistry
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Zheng, Yi; Lei, Qijing; Jongejan, Aldo et al. (2018) The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells. DNA Repair (Amst) 70:55-66
Hwang, Grace H; Hopkins, Jessica L; Jordan, Philip W (2018) Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II. J Vis Exp :
Alexander, Elizabeth J; Ghanbari Niaki, Amirhossein; Zhang, Tao et al. (2018) Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation. Proc Natl Acad Sci U S A 115:E11485-E11494
Wellard, Stephen R; Hopkins, Jessica; Jordan, Philip W (2018) A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model. J Vis Exp :
Cairns, Leah; Tran, Thao; Fowl, Brendan H et al. (2018) Salvador has an extended SARAH domain that mediates binding to Hippo kinase. J Biol Chem 293:5532-5543
McPherson, Robert Lyle; Ong, Shao-En; Leung, Anthony K L (2018) Quantitative Determination of MAR Hydrolase Residue Specificity In Vitro by Tandem Mass Spectrometry. Methods Mol Biol 1813:271-283
Abraham, Rachy; Hauer, Debra; McPherson, Robert Lyle et al. (2018) ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proc Natl Acad Sci U S A 115:E10457-E10466
Jacob, Justin T; Coulombe, Pierre A; Kwan, Raymond et al. (2018) Types I and II Keratin Intermediate Filaments. Cold Spring Harb Perspect Biol 10:
Armstrong, Alissa R; Drummond-Barbosa, Daniela (2018) Insulin signaling acts in adult adipocytes via GSK-3? and independently of FOXO to control Drosophila female germline stem cell numbers. Dev Biol 440:31-39
Leung, Anthony K L; McPherson, Robert Lyle; Griffin, Diane E (2018) Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases. PLoS Pathog 14:e1006864

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