The University of Wisconsin-Madison?s NCI-funded Training Grant in Cancer Biology (T32 CA009135) has supported cancer biology researchers to become successful, independent scientists in academic laboratories or in research-related careers for over 41 years. It is the only NIH/NCI-funded training grant dedicated solely to training in cancer biology research at UW-Madison. We have taken the opportunity to modernize our training program by adding two postdoctoral Oncology Fellows to it. We are requesting 5 predoctoral trainees and 2 postdoctoral Oncology Fellow trainee slots to address current deficiencies in training the next generation of cancer researchers: 1) the growing need for predoctoral trainees to work in translational research; and 2) the demand for the physician-scientists who understand quantitative research. We have reorganized our program administration to be a multi-generational team, added cutting-edge courses to our core curriculum (Bioinformatics, Advanced Grant Writing, and Translational Oncology-Concepts and Study Design), added an annual program retreat, and enhanced the overall training with new seminars, career development workshops, and trainee program evaluations. This training program has four pillars of strength: 1) Trainers/Mentors: Our program includes 31 well-funded faculty mentors and 7 affiliate trainers whose research spans the entire breadth of cancer research from haploid or diploid genetics, viral and chemical carcinogenesis, eukaryotic cell and molecular biology, virology, molecular toxicology, whole-animal carcinogenesis, and translational science. This includes 25 PhDs, 8 MDs, 3 MD/PhDs, and 2 DVM/PhDs from 9 different departments. 2) Trainees: UW- Madison?s nationally competitive biomedical PhD programs allow our trainers to recruit trainees with strong research backgrounds. Our trainers also make it a priority to recruit trainees from under-represented groups. 3) Comprehensive Training Plan: Set in a highly collaborative environment, our training includes intensive one- on-one research mentoring, thorough didactic training in cancer biology, and the commitment to build our trainees? skills in critical-reading, writing, and public speaking. 4) Strong Institutional Support: UW-Madison?s robust predoctoral and postdoctoral training environment adds to our training program by providing newly designed training and administrative support to foster professional development (for example, T32 Cancer Biology Retreat with the University of Minnesota) and bring outstanding speakers to campus (for example, through our Cancer Biology Seminar Series and the UWCCC?s Annual Retreat).

Public Health Relevance

Our goal is to train graduate students and postdoctoral Oncology Fellows to become committed cancer researchers who work to together as scholars, experimentalists, and physician-scientists to advance cancer research and treatment. We have therefore evolved this program to bring graduate students and postdoctoral Oncology Fellows to work side-by-side to grow intellectually and technically. We are particularly proud of this grant because it has allowed us to innovate in our training by developing cutting-edge courses, addressing newly recognized needs of our trainees for their career development, training a more diverse group of students, and simultaneously doing substantive, compelling cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA009135-41A1
Application #
9935309
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Damico, Mark W
Project Start
1975-07-01
Project End
2025-03-31
Budget Start
2020-04-13
Budget End
2021-03-31
Support Year
41
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Bristol, Jillian A; Djavadian, Reza; Albright, Emily R et al. (2018) A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection. PLoS Pathog 14:e1007179
Romero-Masters, James C; Ohashi, Makoto; Djavadian, Reza et al. (2018) An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model. PLoS Pathog 14:e1007221
Huynh, Mailee; Pak, Chorom; Markovina, Stephanie et al. (2018) Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-?B activity and increases drug resistance in multiple myeloma. J Biol Chem 293:2452-2465
Guo, Feng; Wlodarchak, Nathan; Menden, Patrick et al. (2018) Purification of Target Proteins from Native Tissues: CCT Complex from Bovine Testes and PP2Ac from Porcine Brains. Methods Mol Biol 1788:73-88
Barault, Ludovic; Amatu, Alessio; Siravegna, Giulia et al. (2018) Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer. Gut 67:1995-2005
Shea, Michael P; O'Leary, Kathleen A; Fakhraldeen, Saja A et al. (2018) Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ER?+ Mammary Carcinomas. Cancer Res 78:1672-1684
Helzer, Kyle T; Ozers, Mary Szatkowski; Meyer, Mark B et al. (2018) The Phosphorylated Estrogen Receptor Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2. Mol Cell Biol :
Jallow, Fatou; Brockman, Jennifer L; Helzer, Kyle T et al. (2018) 17?-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes. J Endocr Soc 2:293-309
Evans 3rd, Edward L; Becker, Jordan T; Fricke, Stephanie L et al. (2018) HIV-1 Vif's Capacity To Manipulate the Cell Cycle Is Species Specific. J Virol 92:
Damodaran, Shivashankar; Damaschke, Nathan; Gawdzik, Joseph et al. (2017) Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes. BMC Cancer 17:874

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