Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009634-02
Application #
3533790
Study Section
Cancer Institutional Fellowship Review Committee (CT)
Project Start
1990-09-30
Project End
1995-08-31
Budget Start
1991-09-30
Budget End
1992-08-31
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
Organized Research Units
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Woods, James R; Mo, Huaping; Bieberich, Andrew A et al. (2011) Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as (19)f NMR probes in deuterium-free environments. J Med Chem 54:7934-41
Cinelli, Maris A; Morrell, Andrew E; Dexheimer, Thomas S et al. (2010) The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode. Bioorg Med Chem 18:5535-52
Nyland, Rodney L; Luo, Meihua; Kelley, Mark R et al. (2010) Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1). J Med Chem 53:1200-10
Cinelli, Maris A; Morrell, Andrew; Dexheimer, Thomas S et al. (2008) Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors. J Med Chem 51:4609-19
Luo, Meihua; Delaplane, Sarah; Jiang, Aihua et al. (2008) Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1. Antioxid Redox Signal 10:1853-67
Morrell, Andrew; Placzek, Michael; Parmley, Seth et al. (2007) Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors. J Med Chem 50:4388-404
Antony, Smitha; Agama, Keli K; Miao, Ze-Hong et al. (2007) Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Cancer Res 67:10397-405
Morrell, Andrew; Placzek, Michael; Parmley, Seth et al. (2007) Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization. J Med Chem 50:4419-30
Fingerman, Ian M; Li, Hui-Chun; Briggs, Scott D (2007) A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway. Genes Dev 21:2018-29
Morrell, Andrew; Jayaraman, Muthusamy; Nagarajan, Muthukaman et al. (2006) Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay. Bioorg Med Chem Lett 16:4395-9

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