This training program is dedicated toward increasing the number of active clinicians who oversee an extramurally funded basic science research program. Unfortunately, only two percent of physicians are engaged in research and can be identified as physician-scientists. The Education Committee of the Society of University Otolaryngologists concluded that innovative training programs should work to develop research skills in their trainees by providing protected time for research activities. For this reason, the overall goal of the proposed Training Program is to foster the development of research skills (both basic and translational) in selected individuals from the pool of talented otolaryngology residents and fellows at the University of Pittsburgh, who are interested in head and neck oncology. To our knowledge, this is one of the very few training programs in an Otolaryngology residency and an American Head & Neck Society (AHNS) accredited fellowship program supported by the NCI, dedicated to training physician-scientists in the area of head and neck oncology. The unique training opportunities supported by this grant have allowed us to recruit talented trainees who are interested pursuing academic careers in head and neck oncology.
The aims of the program are to: 1) provide training in research methodology that will foster the developing clinician?s ability to become an independent investigator; and 2) to prepare the trainee for an academic career. Interfacing this research program with the Otolaryngology Residency Program and the Fellowship in Advanced Head and Neck Oncologic Surgery provides two outstanding pools of applicants for selection as trainees. It also enables trainees to acquire an education in both clinical skills and basic research approaches, with the ultimate goal of establishing an independent research program. Trainees may choose from preceptors from a wide variety of disciplines in head and neck oncology-related fields to accommodate diverse research backgrounds and interests. In addition, trainees can participate in a unique Research Training Program at the University of Pittsburgh, which is part of the Clinical and Translational Science Institute (CTSI) (3UL1RR024153-03S209), and have the opportunity to take several formal courses, participate in seminar programs and journal clubs, and are also be required to complete the web-based research integrity course offered by the School of Medicine. The trainee?s progress during the Otolaryngology residency program as well as the effectiveness of the preceptor and overall program is monitored and evaluated by an Advisory Committee composed of members of the academic community with extensive training experiences. A second track is embedded within the Fellowship in Advanced Head and Neck Oncologic Surgery, accredited by the American Head and Neck Society. As fellowship director, Dr. Duvvuri and his fellowship selection committee carefully select outstanding candidates with a particular interest in translational research and a career in academic head and neck oncology. These fellows spend at least 2 years, with focused clinical activity, and protected, dedicated research blocks to permit their development of an independent project worth and ready for K-type grant submission by the end of their T32 training period.

Public Health Relevance

This training program is dedicated toward increasing the number of well-trained physicians who also perform basic science studies (do research) in head and neck cancer. We seek to reach this goal through providing training in laboratory techniques, research methodology and preparing the trainees for academic careers in head and neck cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA060397-26
Application #
10024744
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Lim, Susan E
Project Start
1994-06-01
Project End
2025-06-30
Budget Start
2020-07-23
Budget End
2021-06-30
Support Year
26
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
Gleber-Netto, Frederico O; Zhao, Mei; Trivedi, Sanchit et al. (2018) Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer 124:84-94
Liu, Zhuqing; McMichael, Elizabeth L; Shayan, Gulidanna et al. (2018) Novel Effector Phenotype of Tim-3+ Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients. Clin Cancer Res 24:4529-4538
Lu, Shanhong; Concha-Benavente, Fernando; Shayan, Gulidanna et al. (2018) STING activation enhances cetuximab-mediated NK cell activation and DC maturation and correlates with HPV+ status in head and neck cancer. Oral Oncol 78:186-193
Shayan, Gulidanna; Srivastava, Raghvendra; Li, Jing et al. (2017) Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer. Oncoimmunology 6:e1261779
Srivastava, Raghvendra M; Trivedi, Sumita; Concha-Benavente, Fernando et al. (2017) CD137 Stimulation Enhances Cetuximab-Induced Natural Killer: Dendritic Cell Priming of Antitumor T-Cell Immunity in Patients with Head and Neck Cancer. Clin Cancer Res 23:707-716
Kansy, Benjamin A; Concha-Benavente, Fernando; Srivastava, Raghvendra M et al. (2017) PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer. Cancer Res 77:6353-6364
Panebianco, Federica; Kelly, Lindsey M; Liu, Pengyuan et al. (2017) THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer. Proc Natl Acad Sci U S A 114:2307-2312
Albergotti, William G; Gooding, William E; Kubik, Mark W et al. (2017) Assessment of Surgical Learning Curves in Transoral Robotic Surgery for Squamous Cell Carcinoma of the Oropharynx. JAMA Otolaryngol Head Neck Surg 143:542-548
Huyett, Phillip; Gilbert, Mark; Liu, Lijun et al. (2017) A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma. J Vis Exp :
Moy, Jennifer D; Moskovitz, Jessica M; Ferris, Robert L (2017) Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma. Eur J Cancer 76:152-166

Showing the most recent 10 out of 52 publications