Over one million Americans will suffer from cancer every year, and approximately half of them will die from the disease. Despite major efforts to prevent cancer, effective early diagnosis and treatment of non-metastatic disease remains the hallmark of modern effective cancer management. Surgery persists as a major diagnostic and therapeutic modality for the management of cancer, and advances in the technology of surgical technique (such as fiber-optic and radio-nucleotide visualization of normal and diseased tissue and the miniaturization and robotic control of instruments) have contributed to the improved care of the cancer patient. Nonetheless, it is an understanding of the biologic basis of the disease, and the effective diagnostic and therapeutic management of cancer within a multidisciplinary context that will bring the greatest advances over the next decade. In the current era of discovery, the opportunities for the education and training of surgeons in the biologic basis of cancer is unprecedented. The advances in cancer genetics, cell biology and immunology provide important opportunities for basic, translational and clinical studies in cancer research. As the American College of Surgeons Oncology Group has r e l ocated to Duke, an important opportunity to enhance training in translational research for surgeons exists. This opportunity to educate and train future generations of surgical scientists and leaders provided a c o m pelling imperative for this application for a training grant in translational studies in surgical oncology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA093245-02
Application #
6620243
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
2002-01-01
Project End
2006-12-31
Budget Start
2003-02-12
Budget End
2003-12-31
Support Year
2
Fiscal Year
2003
Total Cost
$432,655
Indirect Cost
Name
Duke University
Department
Surgery
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Beasley, Georgia M; Speicher, Paul; Augustine, Christina K et al. (2015) A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion. Ann Surg Oncol 22:287-94
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Speicher, Paul J; Beasley, Georgia M; Jiang, Betty et al. (2014) Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemotherapy for melanoma. Ann Surg Oncol 21:1435-40
Tokuhisa, Yoshihiro; Lidsky, Michael E; Toshimitsu, Hiroaki et al. (2014) SRC family kinase inhibition as a novel strategy to augment melphalan-based regional chemotherapy of advanced extremity melanoma. Ann Surg Oncol 21:1024-30
Lidsky, Michael E; Speicher, Paul J; Jiang, Betty et al. (2014) Isolated limb infusion as a model to test new agents to treat metastatic melanoma. J Surg Oncol 109:357-65

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