This is a new application for training grant support with a single mission: the goal of this T32 program is to train physicians who will be the future academic leaders in basic and/or clinical pediatric oncology research. Reducing the burden of cancer in the pediatric population requires necessitates research across the entire spectrum from fundamental molecular and cellular biologic studies to translational work that bridges the gulf that separates basic research and clinical medicine to clinical investigation. Reducing the burden of cancer in pediatric populations requires broad and intensive training of academic pediatric physicians. An experienced and highly accomplished group of faculty including faculty of the Department of Pediatric Oncology at the Dana Farber Cancer Institute (DFCI), the Division of Pediatric Hematology/Oncology at Children's Hospital Boston (CHB), and additional components of the Harvard Medical School constitute the training faculty for this program. This faculty encompasses basic, translational, and clinical investigation. Trainees will be selected from the combined DFCI-CHB pediatric hematology/oncology fellowship program. Particular emphasis is placed on close mentorship of trainees in the selection of mentors and in on-going oversight during their research. The program is committed to identifying and supporting the most promising fellows, including minority candidates. Over the past 40 years the DFCI-CHB fellowship program has trained >200 individuals, many of whom are leaders and academic pediatric medicine. The proposed T32 program will ensure the continuance and further development of the fellowship program, and promises to contribute immeasurably to the management of children with cancer. While great strides have been made in diagnosis and treatment of pediatric cancers, much remains to be done. Cure of patients is often achieved with unacceptable side-effects, and for many solid tumors current therapy is inadequate. The best hope for reducing the burden of pediatric cancer is the training of committed researchers by an experienced and accomplished faculty that is involved in diverse aspects of basic and clinical research directly relevant to tackling these challenging problems in children.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA136432-05
Application #
8512560
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
2009-07-13
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$503,533
Indirect Cost
$36,311
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Guenther, Lillian M; Dharia, Neekesh V; Ross, Linda et al. (2018) A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma. Clin Cancer Res :
Stolte, Björn; Iniguez, Amanda Balboni; Dharia, Neekesh V et al. (2018) Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med 215:2137-2155
Ng, Samuel Y; Yoshida, Noriaki; Christie, Amanda L et al. (2018) Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nat Commun 9:2024
Guerra, Rachel M; Bird, Gregory H; Harvey, Edward P et al. (2018) Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. Cell Rep 24:3393-3403.e5
Chen, Liying; Alexe, Gabriela; Dharia, Neekesh V et al. (2018) CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. J Clin Invest 128:446-462
Greenzang, Katie A; Cronin, Angel M; Kang, Tammy et al. (2018) Parent understanding of the risk of future limitations secondary to pediatric cancer treatment. Pediatr Blood Cancer 65:e27020
Marron, Jonathan M; Jones, Emma; Wolfe, Joanne (2018) Is There Ever a Role for the Unilateral Do Not Attempt Resuscitation Order in Pediatric Care? J Pain Symptom Manage 55:164-171
Greenzang, Katie A; Dauti, Angela; Mack, Jennifer W (2018) Parent perspectives on information about late effects of childhood cancer treatment and their role in initial treatment decision making. Pediatr Blood Cancer 65:e26978
Ozuah, Nmazuo W; Marcus, Karen J; LaCasce, Ann S et al. (2018) Excellent Outcomes Following Response-based Omission of Radiotherapy in Children and Adolescents With Intermediate or High-risk Hodgkin Lymphoma. J Pediatr Hematol Oncol 40:e338-e342
Marron, Jonathan M; Cronin, Angel M; Kang, Tammy I et al. (2018) Intended and unintended consequences: Ethics, communication, and prognostic disclosure in pediatric oncology. Cancer 124:1232-1241

Showing the most recent 10 out of 22 publications